Astragalus polysaccharide promotes the release of mature granulocytes through the L-selectin signaling pathway

This study aims to investigate the leukogenic effect of astragalus polysaccharide (APS), to compare its effect of increasing the numbers of mature granulocytes with that of granulocyte colony-stimulating factor (G-CSF), and to investigate the mechanism. Rats were arbitrarily grouped into four groups...

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Bibliographic Details
Published in:Chinese medicine 2015-07, Vol.10 (1), p.17-17, Article 17
Main Authors: Zhang, Ping-Ping, Meng, Zhao-Ting, Wang, Liu-Chun, Guo, Lei-Ming, Li, Kai
Format: Article
Language:English
Subjects:
Analysis
Cancer
Chemical properties
Chemotherapy
Cyclophosphamide
Granulocyte colony-stimulating factor
Health aspects
Polysaccharides
Proteases
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Summary:This study aims to investigate the leukogenic effect of astragalus polysaccharide (APS), to compare its effect of increasing the numbers of mature granulocytes with that of granulocyte colony-stimulating factor (G-CSF), and to investigate the mechanism. Rats were arbitrarily grouped into four groups (control, cyclophosphamide (CTX), CTX + APS, and CTX + G-CSF groups), and each group was then arbitrarily divided into five subgroups according to the time period since CTX infusion (0, 4, 7, 10, and 14 days). The expression of leukocyte selectin (L-selectin), its ligand, and shedding-related protease on granulocytes was analyzed. Leukocyte counts were obtained. Chemotactic capacity of polymorphonuclear leukocytes (PMNLs) was assessed. Both APS and G-CSF restored the expression of L-selectin, P-selectin glycoprotein ligand-1 (PSGL-1), CD11b/CD18, and ADAM17 to normal levels (P > 0.05 vs. control group on each time point), with APS eliciting a greater effect than G-CSF (P = 0.005 on day 7, P 
ISSN:1749-8546
1749-8546
DOI:10.1186/s13020-015-0043-z