A Randomized Trial to Compare the Safety, Tolerability, and Effectiveness of 3 Antimalarial Regimens for the Prevention of Malaria in Nigerian Patients With Sickle Cell Disease

Background. Malaria prophylaxis is recommended for persons with sickle cell disease (SCD), but the value of this has been questioned. The aim of this study was to find out whether intermittent preventive treatment (IPT) with a fixed-dose combination of mefloquine-artesunate (MQAS) or sulfadoxine-pyr...

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Published in:The Journal of infectious diseases 2015-08, Vol.212 (4), p.617-625
Main Authors: Olaosebikan, Rasaq, Ernest, Kolade, Bojang, Kalifa, Mokuolu, Olugbenga, Rehman, Andrea M., Affara, Muna, Nwakanma, Davis, Kiechel, Jean-René, Ogunkunle, Taofik, Olagunju, Tope, Murtala, Rukayat, Omefe, Peter, Lambe, Tosin, Bello, Surajudeen, Ibrahim, Olayinka, Olorunsola, Benedict, Ojuawo, Ayotade, Greenwood, Brian, Milligan, Paul
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anemia, Sickle Cell - complications
Antimalarials - administration & dosage
Antimalarials - adverse effects
Antimalarials - therapeutic use
Child
Child, Preschool
Female
Humans
Major and Brief Reports
Malaria - complications
Malaria - epidemiology
Malaria - prevention & control
Male
Medication Adherence
Nigeria - epidemiology
PARASITES
Young Adult
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Summary:Background. Malaria prophylaxis is recommended for persons with sickle cell disease (SCD), but the value of this has been questioned. The aim of this study was to find out whether intermittent preventive treatment (IPT) with a fixed-dose combination of mefloquine-artesunate (MQAS) or sulfadoxine-pyrimethamine plus amodiaquine (SPAQ) was more effective than daily proguanil for malaria prevention in subjects with SCD. Methods. Patients with SCD were randomized to receive daily treatment with proguanil or IPT with either MQAS or SPAQ once every 2 months at routine clinic visits. Patients were followed up for 14 months. Findings. A total of 270 patients with SCD were studied, with 90 in each group. Adherence to the IPT regimens was excellent, but 57% of patients took
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiv093