Downstream processing and chromatography based analytical methods for production of vaccines, gene therapy vectors, and bacteriophages

Downstream processing of nanoplexes (viruses, virus-like particles, bacteriophages) is characterized by complexity of the starting material, number of purification methods to choose from, regulations that are setting the frame for the final product and analytical methods for upstream and downstream...

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Bibliographic Details
Published in:Human vaccines & immunotherapeutics 2015-04, Vol.11 (4), p.1010-1021
Main Authors: Kramberger, Petra, Urbas, Lidija, Štrancar, Aleš
Format: Article
Language:English
Subjects:
bacteriophage
Bacteriophages - metabolism
Chromatography - methods
CIM monolithic column
DSP
gene therapy vector
Genetic Therapy
Genetic Vectors
PAT
purification
Review
USP
vaccine
Vaccines - biosynthesis
virus
VLP
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Summary:Downstream processing of nanoplexes (viruses, virus-like particles, bacteriophages) is characterized by complexity of the starting material, number of purification methods to choose from, regulations that are setting the frame for the final product and analytical methods for upstream and downstream monitoring. This review gives an overview on the nanoplex downstream challenges and chromatography based analytical methods for efficient monitoring of the nanoplex production.
ISSN:2164-5515
2164-554X
DOI:10.1080/21645515.2015.1009817