Relationship Between Skin Intrinsic Fluorescence--an Indicator of Advanced Glycation End Products-and Upper Extremity Impairments in Individuals With Diabetes Mellitus

Accumulation of advanced glycation end products (AGEs) is thought to contribute to limited joint mobility in people with diabetes mellitus (DM), but the relationships among AGEs, shoulder structural changes, movement, and disability are not understood. The purpose of this study was to determine the...

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Bibliographic Details
Published in:Physical therapy 2015-08, Vol.95 (8), p.1111-1119
Main Authors: Shah, Kshamata M, Clark, B Ruth, McGill, Janet B, Lang, Catherine E, Maynard, John, Mueller, Michael J
Format: Article
Language:English
Subjects:
Advanced glycation end products
Aged
Body mass index
Case-Control Studies
Collagen
Complications and side effects
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - physiopathology
Disabilities
Disability
Disability Evaluation
Female
Fluorescence
Glycation End Products, Advanced - metabolism
Health aspects
Humans
Kinematics
Male
Middle Aged
Research Reports
Risk factors
Shoulder
Skin
Skin - metabolism
Upper Extremity - physiopathology
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Summary:Accumulation of advanced glycation end products (AGEs) is thought to contribute to limited joint mobility in people with diabetes mellitus (DM), but the relationships among AGEs, shoulder structural changes, movement, and disability are not understood. The purpose of this study was to determine the differences and relationships among skin intrinsic fluorescence (SIF), a proxy measure of AGEs, biceps and supraspinatus tendon thickness, upper extremity movement, and disability in groups with and without DM. This was a cross-sectional, case-control study. Fifty-two individuals participated: 26 with type 2 DM and 26 controls matched for sex, age, and body mass index. The main outcome measures were: SIF; biceps and supraspinatus tendon thickness; 3-dimensional peak shoulder motion; and Disability of the Arm, Shoulder and Hand (DASH) questionnaire scores. Mean SIF measurements were 19% higher in the DM group compared with the control group (P
ISSN:0031-9023
1538-6724
DOI:10.2522/ptj.20140340