Treatment with near-infrared radiation promotes apoptosis in pancreatic cancer cells

Cancer remains one of the leading causes of human mortality worldwide. Radiation and chemotherapy are commonly used for cancer treatment; however, the combination of these therapies and surgery do not completely eradicate cancer cells. Near-infrared radiation (NIR) is a low-energy form of radiation...

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Bibliographic Details
Published in:Oncology letters 2015-09, Vol.10 (3), p.1836-1840
Main Authors: OBAYASHI, TOMOHIKO, FUNASAKA, KOHEI, OHNO, EIZABURO, MIYAHARA, RYOJI, HIROOKA, YOSHIKI, HAMAGUCHI, MICHINARI, GOTO, HIDEMI, SENGA, TAKESHI
Format: Article
Language:English
Subjects:
Apoptosis
Cancer therapies
Care and treatment
caspase-3
Cell cycle
Cell growth
Charged particles
Chemotherapy
Cytochrome
Cytotoxicity
Deoxyribonucleic acid
DNA
Gallium arsenide
gemcitabine
Health aspects
Lasers
Medical prognosis
Methods
Microscopy
Mortality
near-infrared radiation
Oncology
Pancreatic cancer
Patient outcomes
Radiotherapy
Rodents
Studies
Temperature
Thermal energy
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Summary:Cancer remains one of the leading causes of human mortality worldwide. Radiation and chemotherapy are commonly used for cancer treatment; however, the combination of these therapies and surgery do not completely eradicate cancer cells. Near-infrared radiation (NIR) is a low-energy form of radiation that exerts multiple effects on mammalian cells. Previous studies have reported that NIR induces DNA double-strand breaks and apoptosis of cancer cells. In the present study, a 915-nm laser was used to examine the effects of NIR on pancreatic cancer cells. Irradiation of pancreatic cancer cells using a 915-nm laser significantly induced caspase-3 activation and apoptosis. In addition, the combination of gemcitabine treatment and a 915-nm laser synergistically increased the number of apoptotic cells. The results of the present study indicate the use of infrared irradiation and chemotherapy may be a possible therapy for the treatment of cancer.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2015.3399