Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats

Status epilepticus (SE) is a severe condition that may lead to hippocampal cell loss and epileptogenesis. Some of the mechanisms associated with SE-induced cell death are excitotoxicity, neuroinflammation, and apoptosis. The objective of the present study is to test the hypothesis that DBS has anti-...

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Bibliographic Details
Published in:Journal of neuroinflammation 2015-09, Vol.12 (1), p.162, Article 162
Main Authors: Amorim, Beatriz O, Covolan, Luciene, Ferreira, Elenn, Brito, José Geraldo, Nunes, Diego P, de Morais, David G, Nobrega, José N, Rodrigues, Antonio M, deAlmeida, Antonio Carlos G, Hamani, Clement
Format: Article
Language:English
Subjects:
Analysis
Analysis of Variance
Animals
Anti-inflammatory drugs
Apoptosis - drug effects
Apoptosis - physiology
Care and treatment
Caspase 3 - metabolism
Cell death
Complications and side effects
Cytokines - metabolism
Deep Brain Stimulation - methods
Disease Models, Animal
Electroencephalography
Encephalitis - etiology
Encephalitis - therapy
Epilepsy
Hippocampus - metabolism
Interleukins
Male
Muscarinic Agonists
Neurophysiology
Pilocarpine - toxicity
Rats
Rats, Wistar
Risk factors
Seizures (Medicine)
Short Report
Status Epilepticus - chemically induced
Status Epilepticus - complications
Status Epilepticus - pathology
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Summary:Status epilepticus (SE) is a severe condition that may lead to hippocampal cell loss and epileptogenesis. Some of the mechanisms associated with SE-induced cell death are excitotoxicity, neuroinflammation, and apoptosis. The objective of the present study is to test the hypothesis that DBS has anti-inflammatory and antiapoptotic effects when applied during SE. Rats undergoing pilocarpine-induced SE were treated with anterior thalamic nucleus (AN) deep brain stimulation (DBS). Inflammatory changes and caspase 3 activity were measured within 1 week of treatment. In pilocarpine-treated rats, DBS countered the significant increase in hippocampal caspase 3 activity and interleukin-6 (IL-6) levels that follows SE but had no effect on tumor necrosis factor α (TNFα). DBS has anti-inflammatory and antiapoptotic effects when given to animals undergoing status.
ISSN:1742-2094
1742-2094
DOI:10.1186/s12974-015-0384-7