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Pre-existing levels of CD4 T cells expressing PD-1 are related to overall survival in prostate cancer patients treated with ipilimumab

CTL-associated antigen 4 (CTLA-4) blockade can induce tumor regression and improved survival in cancer patients. This treatment can enhance adaptive immune responses without an exogenous vaccine, but the immunologic biomarkers associated with improved clinical outcome in cancer patients are not full...

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Bibliographic Details
Published in:Cancer immunology research 2015-05, Vol.3 (9), p.1008-1016
Main Authors: Kwek, Serena S., Lewis, Jera, Zhang, Li, Weinberg, Vivian, Greaney, Samantha, Harzstark, Andrea, Lin, Amy, Ryan, Charles, Small, Eric J., Fong, Lawrence
Format: Article
Language:English
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Summary:CTL-associated antigen 4 (CTLA-4) blockade can induce tumor regression and improved survival in cancer patients. This treatment can enhance adaptive immune responses without an exogenous vaccine, but the immunologic biomarkers associated with improved clinical outcome in cancer patients are not fully established. A phase Ib trial in patients with metastatic, castration resistant prostate cancer (mCRPC) was performed combining ipilimumab with sargramostim (GM-CSF). In addition to evaluating ipilimumab dose, patients were followed clinically for response and overall survival, and for immunomodulation of circulating T cells. PSA declines of ≥50% and radiographic responses were observed at doses of ≥3 mg/kg/dose. Timing of clinical responses could be either immediate or delayed. Durable responses were also observed off treatment. A subset of patients experienced long-term survival with or without objective clinical responses. The relationship between T-cell phenotype in peripheral blood and overall survival were examined retrospectively. We found that the treatment induced an increase in the levels of CD4 + effector T (T eff ) cells, regulatory T (T reg ) cells, PD-1 + CD4 T eff cells, and PD-1 + CD8 T cells. However, these increased levels were not associated with overall survival. Instead, low pre-treatment baseline levels of PD-1 + CD4 T eff cells were found to correlate with longer overall survival. Furthermore, baseline levels of PD-1 + CD4 T eff cells from patients with shorter overall survival were higher than from cancer-free male controls. These results suggest that pre-existing expression of immunologic checkpoint marker PD-1 on CD4 T eff cells may help identify patients that may benefit from ipilimumab treatment.
ISSN:2326-6066
2326-6074
DOI:10.1158/2326-6066.CIR-14-0227