Genetic clustering of recent classical swine fever virus isolates from Karnataka, India revealed the emergence of subtype 2.2 replacing subtype 1.1

The phylogenetic analysis of 11 CSFV isolates from Karnataka, India obtained during the year 2012–13 was undertaken to obtain the most reliable genetic typing of the CSFV isolates based on E2, NS5B and 5′UTR genomic regions. The study indicated that all the 11 CSFV isolates belonged to subgroup 2.2....

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Bibliographic Details
Published in:Virusdisease 2015-09, Vol.26 (3), p.170-179
Main Authors: Shivaraj, D. B., Patil, S. S., Rathnamma, D., Hemadri, D., Isloor, S., Geetha, S., Manjunathareddy, G. B., Gajendragad, M. R., Rahman, H.
Format: Article
Language:English
Subjects:
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Biochemistry
Biomedical and Life Sciences
Cell Biology
Congenital diseases
Disease
Epidemics
Epidemiology
Fever
Genomes
Hog cholera
Hogs
Immunization
Laboratories
Life Sciences
Microbiology
Original
Original Article
Outbreaks
Phylogenetics
Phylogeny
Protein Structure
Thermal cycling
Trees
Viruses
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Summary:The phylogenetic analysis of 11 CSFV isolates from Karnataka, India obtained during the year 2012–13 was undertaken to obtain the most reliable genetic typing of the CSFV isolates based on E2, NS5B and 5′UTR genomic regions. The study indicated that all the 11 CSFV isolates belonged to subgroup 2.2. The most reliable classification was obtained with sequence data from the NS5B region which separated all the isolates based on the history of outbreak and geographic origin. Analysis of full length E2 amino acid sequences revealed different genetic makeup of Indian 2.2 isolates compared to 2.2 isolates from different countries. The group 2.2 viruses are gradually spreading as confirmed by frequent detection/ isolation of group 2.2 viruses in the recent years and replacing the subgroup 1.1 viruses, which were hitherto predominantly involved in CSF outbreaks in India.
ISSN:2347-3584
2347-3517
DOI:10.1007/s13337-015-0273-9