The impact of long-term changes in metabolic status on cardiovascular biomarkers and microvascular endothelial function in middle-aged men: a 25-year prospective study

• Published in: Diabetology and metabolic syndrome 2015-09, Vol.7 (1), p.81-81, Article 81
• Main Authors: Kwaśniewska, Magdalena, Kozińska, Joanna, Dziankowska-Zaborszczyk, Elżbieta, Kostka, Tomasz, Jegier, Anna, Rębowska, Ewa, Orczykowska, Milena, Leszczyńska, Joanna, Drygas, Wojciech
• Format: Article
• Language: English
• Subjects: Biological markers; Cardiovascular diseases; Diagnosis; Endothelium; Enzyme-linked immunosorbent assay; Enzymes; Exercise; Leptin; Low density lipoproteins; Physiological aspects; Risk factors; Triglycerides; Uric acid
• ISSN: 1758-5996; 1758-5996
• DOI: 10.1186/s13098-015-0074-8

The aim of this analysis was to examine long-term effects of changes in metabolic status on microvascular endothelial function and cardiovascular diseases (CVD) biomarkers among physically active middle-aged men. Metabolically healthy men (n = 101, mean age 59.7 years), free of symptoms and treatment, have been prospectively observed for their lifestyle and CVD risk factors (observation period 24.7 years). At the latest follow-up (2011/2012) a set of CVD biomarkers was measured using enzyme-linked immunosorbent assay. Microvascular endothelial function was evaluated by means of the reactive hyperemia index (RHI) using Endo-PAT2000 system. At follow-up the participants were divided into metabolically healthy (0-1 metabolic parameters) and metabolically unhealthy (≥2 metabolic parameters) groups. Metabolic syndrome was defined according to the NCEP ATP III definition. Traditional metabolic risk factors were significantly associated with hsCRP, ox-LDL, Il-6, leptin and adiponectin/leptin ratio. Reactive hyperemia index was negatively related to body mass (p