Maternal and fetal oxidative stress and intrapartum term fever

Objective The association between maternal chorioamnionitis and fetal oxidative stress has not been well established. Study Design A nested case control study was performed within a prospective cohort of term nulliparous women: 20 cases (intrapartum fever of >100.4°F) and 20 afebrile controls. Ox...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2010-04, Vol.202 (4), p.363.e1-363.e5
Main Authors: Goetzl, Laura, MD, MPH, Manevich, Yefim, PhD, Roedner, Chantel, BA, Praktish, Allison, BS, Hebbar, Latha, MD, Townsend, Danyelle M., PhD
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Chorioamnionitis - metabolism
Female
fetal neuroprotection
fever
Fever - metabolism
Humans
Infant, Newborn
Infant, Newborn, Diseases - metabolism
inflammation
intrapartum fever
Labor Stage, First - metabolism
Obstetric Labor Complications - metabolism
Obstetrics and Gynecology
Oxidative Stress
Pregnancy
Pregnancy Complications - metabolism
Seizures, Febrile - metabolism
Sepsis - metabolism
Young Adult
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Summary:Objective The association between maternal chorioamnionitis and fetal oxidative stress has not been well established. Study Design A nested case control study was performed within a prospective cohort of term nulliparous women: 20 cases (intrapartum fever of >100.4°F) and 20 afebrile controls. Oxidative stress was assessed using ThioGlo-1 (TG-1; Calbiochem, San Diego, CA) fluorescent sulfhydryl detection. Median levels (± interquartile range) of protein-thiol sulfhydryls were compared. Results In early labor, maternal oxidative stress (lower protein sulfhydryls) was significantly higher in those women who subsequently had intrapartum fever develop (79.87 ± 22.88 vs 127.73 ± 43.79 counts/second per μg protein; P < .001). In contrast, cord serum sulfhydryls were not different between groups (75.77 ± 14.00 vs 75.04 ± 17.83 counts/second per μg protein; P = .99) Conclusion Our data suggest that the term human fetus is protected from maternal oxidative stress associated with intrapartum fever. However, maternal oxidative status in early labor is associated with subsequent intrapartum fever. Optimal fetal neuroprotection will require a more precise knowledge of pathogenic mechanisms.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2010.01.034