Neuroendocrine cell populations in normal human lungs: a quantitative study

Pulmonary neuroendocrine cells, identified by their positive immunochemical reaction for neurone specific enolase, were readily demonstrable and uniformly distributed in 15 pairs of normal adult human lungs. About 65% contained gastrin releasing peptide and nearly all the rest contained calcitonin....

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Bibliographic Details
Published in:Thorax 1988-11, Vol.43 (11), p.878-882
Main Authors: Gosney, J R, Sissons, M C, Allibone, R O
Format: Article
Language:English
Subjects:
Aged
Air breathing
Biological and medical sciences
Calcitonin - metabolism
Cell Count
Female
Fundamental and applied biological sciences. Psychology
Gastrin-Releasing Peptide
Humans
Immunoenzyme Techniques
Lung - cytology
Lung - metabolism
Male
Neurosecretory Systems - cytology
Peptides - metabolism
Phosphopyruvate Hydratase - metabolism
Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics
Vertebrates: respiratory system
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Summary:Pulmonary neuroendocrine cells, identified by their positive immunochemical reaction for neurone specific enolase, were readily demonstrable and uniformly distributed in 15 pairs of normal adult human lungs. About 65% contained gastrin releasing peptide and nearly all the rest contained calcitonin. Leucine-enkephalin was not found. Serotonin containing cells were few, and cells immunoreactive for adrenocorticotrophin and antidiuretic hormone were absent. About one in 10 cells was argyrophilic, and costorage of peptides was not seen.
ISSN:0040-6376
1468-3296
DOI:10.1136/thx.43.11.878