Expression and significance of PTEN, hypoxia-inducible factor-1 alpha in colorectal adenoma and adenocarcinoma

To investigate the expression and significance of PTEN, hypoxia-inducible factor-1 alpha (HIF-1alpha), and targeting gene VEGF during colorectal carciogenesis. Total 71 cases colorectal neoplasms (9 cases of colorectal adenoma and 62 colorectal adenocarcinoma) were formalin fixed and paraffin-embedd...

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Published in:World journal of gastroenterology : WJG 2003-03, Vol.9 (3), p.491-494
Main Authors: Jiang, Ying-An, Fan, Li-Fang, Jiang, Chong-Qing, Zhang, You-Yuan, Luo, He-Sheng, Tang, Zhi-Jiao, Xia, Dong, Wang, Ming
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Adenoma - metabolism
Adenoma - pathology
Colorectal Cancer
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
DNA-Binding Proteins - metabolism
Humans
Hypoxia-Inducible Factor 1
Hypoxia-Inducible Factor 1, alpha Subunit
Nuclear Proteins - metabolism
Phosphoric Monoester Hydrolases - metabolism
PTEN Phosphohydrolase
Transcription Factors
Tumor Suppressor Proteins - metabolism
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Summary:To investigate the expression and significance of PTEN, hypoxia-inducible factor-1 alpha (HIF-1alpha), and targeting gene VEGF during colorectal carciogenesis. Total 71 cases colorectal neoplasms (9 cases of colorectal adenoma and 62 colorectal adenocarcinoma) were formalin fixed and paraffin-embedded, and all specimens were evaluated for PTEN mRNA, HIF-1alpha mRNA and VEGF protein expression. PTEN mRNA, HIF-1alpha mRNA were detected by in situ hybridization. VEGF protein was identified by citrate-microwave SP immunohistochemical method. There were significant differences in PTEN, HIF-1alpha and VEGF expression between colorectal adenomas and colorectal adenocarcinoma (P
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v9.i3.491