Acute aerobic exercise increases exogenously infused bone marrow cell retention in the heart

• Published in: Physiological reports 2015-10, Vol.3 (10), p.e12566-n/a
• Main Authors: Chirico, Erica N., Ding, Dennis, Muthukumaran, Geetha, Houser, Steven R., Starosta, Tim, Mu, Anbin, Margulies, Kenneth B., Libonati, Joseph R.
• Format: Article
• Language: English
• Subjects: Adult stem cells; Aerobics; Bone marrow; Cardiac function; Cardiomyocytes; Cell adhesion molecules; Cell cycle; Cryoinjury; Echocardiography; Exercise; Experiments; Fitness equipment; Fitness training programs; Gene expression; Heart; Heart attacks; Myocardial infarction; Original Research; Ostomy; Physical fitness; Physiology; Rehabilitation; Retention; Stem cells; Studies; Ultrasonic imaging; Ventricle
• ISSN: 2051-817X; 2051-817X
• DOI: 10.14814/phy2.12566

Stem cell therapy for myocardial infarction (MI) has been shown to improve cardiac function and reduce infarct size. Exercise training, in the form of cardiac rehabilitation, is an essential part of patient care post‐MI. Hence, we tested the effects of acute and chronic aerobic exercise on stem cell retention and cardiac remodeling post‐MI. Small epicardial MI's were induced in 12‐month‐old C57BL/6 mice via cryoinjury. Two weeks post‐MI, vehicle infusion (N = 4) or GFP+ bone marrow‐derived cells (BMC) were injected (tail vein I.V.) immediately after acute exercise (N = 14) or sedentary conditions (N = 14). A subset of mice continued a 5‐week intervention of chronic treadmill exercise (10–13 m/min; 45 min/day; 4 days/week; N = 7) or remained sedentary (N = 6). Exercise tolerance was assessed using a graded exercise test, and cardiac function was assessed with echocardiography. Acute exercise increased GFP+ BMC retention in the infarcted zone of the heart by 30% versus sedentary (P