ZFX is a Strong Predictor of Poor Prognosis in Renal Cell Carcinoma

This study was designed to assay the expression of zinc finger protein X-linked (ZFX) in renal cell carcinoma (RCC) tissues and evaluate the correlation between ZFX expression and prognosis of RCC patients. The expressions of ZFX mRNA in 53 RCC tissues and 51 normal tissues were determined by quanti...

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Bibliographic Details
Published in:Medical science monitor 2015-11, Vol.21, p.3380-3385
Main Authors: Li, Changying, Li, Hongjie, Zhang, Ting, Li, Jianmin, Ma, Fuling, Li, Mei, Sui, Zhifang, Chang, Jiwu
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Renal Cell - diagnosis
Carcinoma, Renal Cell - metabolism
Carcinoma, Renal Cell - mortality
Clinical Research
Disease Progression
Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Kidney Neoplasms - diagnosis
Kidney Neoplasms - metabolism
Kidney Neoplasms - mortality
Kruppel-Like Transcription Factors - genetics
Kruppel-Like Transcription Factors - metabolism
Male
Middle Aged
Prognosis
Proportional Hazards Models
Real-Time Polymerase Chain Reaction
Regression Analysis
Survival Rate
Zinc Fingers
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Summary:This study was designed to assay the expression of zinc finger protein X-linked (ZFX) in renal cell carcinoma (RCC) tissues and evaluate the correlation between ZFX expression and prognosis of RCC patients. The expressions of ZFX mRNA in 53 RCC tissues and 51 normal tissues were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Immunohistochemistry (IHC) technology was used to measure the expression of ZFX protein. Then chi-square test was conducted to verify the association between ZFX expression and clinical parameters. Next, we explored the overall survival rate of RCC patients with Kaplan-Meier analysis. Finally, the correlation between ZFX expression and the prognosis of RCC patients was evaluated by Cox regression analysis. The qRT-PCR result showed that the ZFX was significantly up-regulated in RCC tissues. As for the IHC consequence, the positive rate of ZFX expression in RCC specimens was 79.2%, while that in the normal control tissues was only 17.6%. Chi-square test showed that ZFX expression shared no close relationship with age, sex, or smoking (P>0.05), but was tightly associated with TNM stage, tumor size, and lymph node metastasis (P
ISSN:1643-3750
1234-1010
1643-3750
DOI:10.12659/MSM.894708