Live virus vaccines based on a yellow fever vaccine backbone: Standardized template with key considerations for a risk/benefit assessment

Highlights • The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) evaluates vaccine safety. • Many recombinant viral vectored vaccines are in advanced clinical trials. • A template is presented for evaluating live recombinant flavivirus vaccines in which genes for envelope p...

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Bibliographic Details
Published in:Vaccine 2015-01, Vol.33 (1), p.62-72
Main Authors: Monath, Thomas P, Seligman, Stephen J, Robertson, James S, Guy, Bruno, Hayes, Edward B, Condit, Richard C, Excler, Jean Louis, Mac, Lisa Marie, Carbery, Baevin, Chen, Robert T
Format: Article
Language:English
Subjects:
Allergy and Immunology
Australia
Brighton Collaboration
chimerism
clinical trials
Collaboration
Comparative studies
dengue
Drug Carriers
encephalitis
Fever
Flavivirus
genes
Genetic Vectors
Genomes
Humans
Malalties víriques
Malaysia
marketing
Medical research
Medicina tropical
Mosquitoes
mutation
Philippines
proteins
Randomized Controlled Trials as Topic
risk
Risk Assessment
Risk/benefit assessment
Safety
serotypes
stakeholders
Thailand
Tropical diseases
Tropical medicine
Vaccine safety
Vaccines
Vaccines, Attenuated - adverse effects
Vaccines, Attenuated - genetics
Vaccines, Synthetic - adverse effects
Vaccines, Synthetic - genetics
Vacunes antivíriques
vector vaccines
Vector-borne diseases
Vectors genètics
Viral vaccines
Viral Vaccines - adverse effects
Viral Vaccines - genetics
Viral vector
Virus diseases
Viruses
Yellow fever vaccine
Yellow fever virus
Yellow fever virus - genetics
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Description
Summary:Highlights • The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) evaluates vaccine safety. • Many recombinant viral vectored vaccines are in advanced clinical trials. • A template is presented for evaluating live recombinant flavivirus vaccines in which genes for envelope proteins have replaced the corresponding genes in yellow fever virus vaccine. • The template can be used as a model for other live recombinant viral vaccines.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.10.004