Significance of androgen receptor and CD10 expression in cutaneous basal cell carcinoma and trichoepithelioma

Differential diagnosis of trichoepithelioma (TE) and basal cell carcinoma (BCC) on the basis of clinical symptoms and laboratory investigations may be difficult in certain patients. The aim of the present study was to compare cluster of differentiation 10 (CD10) and androgen receptor (AR) expression...

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Bibliographic Details
Published in:Oncology letters 2015-12, Vol.10 (6), p.3466-3470
Main Authors: ASTARCI, HESNA M, GURBUZ, GULFEM A, SENGUL, DEMET, HUCUMENOGLU, SEMA, KOCER, UGUR, USTUN, HUSEYIN
Format: Article
Language:English
Subjects:
Alcohol
androgen receptor
Androgens
Antigens
basal cell carcinoma
Calcification
CD10
Cellular proteins
Cloning
Cysts
Development and progression
Gene expression
Genetic aspects
Genetic markers
Health aspects
Identification and classification
immunohistochemistry
Laboratories
Oncology
Properties
Skin cancer
trichoepithelioma
Tumors
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Summary:Differential diagnosis of trichoepithelioma (TE) and basal cell carcinoma (BCC) on the basis of clinical symptoms and laboratory investigations may be difficult in certain patients. The aim of the present study was to compare cluster of differentiation 10 (CD10) and androgen receptor (AR) expression patterns in BCC and TE, to investigate the predictive power of these proteins as markers of the two conditions. A total of 39 cases of BCC and 15 cases of TE were retrieved from the pathology department archives. AR and CD10 immunohistochemistry was performed on all of the specimens; 23 BCC cases displayed focal nuclear AR staining, however, none of the cases demonstrated diffuse nuclear staining and 16 BCC cases were negative for AR staining. Stromal CD10 staining was more common in TE cases than in BCC cases, and peripheral CD10 staining was more common in BCC cases than in TE cases. AR immunostaining of the BCC samples typically appeared as scattered clusters and individual cells. In addition, AR and CD10 staining exhibited varying staining intensities within each samples. Incisional punch biopsy specimens have the potential to present false-negative results. Therefore, AR and CD10 staining of total excision biopsies provides a more accurate differential diagnosis of BCC and TE for cases with difficulties in the histopathological analysis.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2015.3804