The Validity of Self-reported Recent Smoking in Head and Neck Cancer Surgical Patients

• Published in: Otolaryngology-head and neck surgery 2015-12, Vol.153 (6), p.990-995
• Main Authors: Alberg, Anthony J., Worley, Mitchell L., Tooze, Janet A., Hatcher, Jeanne L., Carpenter, Matthew J., Day, Terry A., Sullivan, Christopher A., Warren, Graham W., Sterba, Katherine R., Weaver, Kathryn E.
• Format: Article
• Language: English
• Subjects: cancer patients; cigarette smoking; cotinine; Cotinine - urine; Cross-Sectional Studies; False Negative Reactions; Female; Head and Neck Neoplasms - surgery; Humans; Male; measurement of smoking status; Middle Aged; Reproducibility of Results; research methods; Self Disclosure; Smoking; validity
• ISSN: 0194-5998; 1097-6817
• DOI: 10.1177/0194599815594385

Objective In cancer patients, cigarette smoking causes poorer response to treatment, treatment toxicity, increased risk of recurrence, higher surgical complication rates, and poorer overall survival. As such a significant determinant of patient prognosis, accurate classification of current smoking status is important. Self-reported smoking status may lead to misclassification if patients conceal their true status. The purpose of this study was to assess the validity of self-reported tobacco use during the previous 48 hours in head and neck cancer patients on the day of surgery. Study Design Cross-sectional. Setting Two academic medical centers in the southeastern United States. Subjects and Methods On the day of surgery, 108 head and neck cancer patients completed a survey asking about tobacco use during the past 48 hours and had semi-quantitative levels of urinary cotinine measured to biochemically validate self-reported recent smoking. Results Self-reported smoking yielded a sensitivity of 60.9% (95% CI, 45.4%-74.9%) and a specificity of 98.4% (95% CI, 91.3%-100.0%). The sensitivity increased to 76.1% (95% CI, 61.2%-87.4%) when allowing for the possibility that exposure to secondhand smoke or use of nicotine-containing products could have caused a positive cotinine test. Conclusion In this patient population, self-reported recent smoking yielded a high (39%) proportion of false-negatives, and even 24% remained false-negatives after allowing for other sources of nicotine exposure. This magnitude of underreporting combined with the importance of tobacco use to patient prognosis supports the need for routinely biochemically verifying recent tobacco use in self-reported nonsmokers within the clinical setting.