Preventive effects of vitamin D treatment on bleomycin-induced pulmonary fibrosis

Patients with pulmonary fibrosis often have low vitamin D levels, the effects of which are largely unknown. We here report that early vitamin D supplementation significantly reduced the severity of pulmonary fibrosis and inflammatory cell accumulationin in the bleomycin-induced pulmonary fibrosis mo...

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Bibliographic Details
Published in:Scientific reports 2015-12, Vol.5 (1), p.17638, Article 17638
Main Authors: Zhang, Zongmei, Yu, Xiaoting, Fang, Xia, Liang, Aibin, Yu, Zhang, Gu, Pan, Zeng, Yu, He, Jian, Zhu, Hailong, Li, Shuai, Fan, Desheng, Han, Fei, Zhang, Lanjing, Yi, Xianghua
Format: Article
Language:English
Subjects:
13/51
14/28
38/77
64/60
692/308/1426
692/699/1785
Actin
Animals
Bleomycin
Bleomycin - adverse effects
Bleomycin - pharmacology
Densitometry
Dietary Supplements
Fibrin
Fibrin - metabolism
Fibrosis
Humanities and Social Sciences
Hydroxyproline
Hydroxyproline - metabolism
Immunohistochemistry
Inflammation
Interferon
Lung diseases
Male
Mice
multidisciplinary
Pulmonary fibrosis
Pulmonary Fibrosis - chemically induced
Pulmonary Fibrosis - metabolism
Pulmonary Fibrosis - pathology
Pulmonary Fibrosis - prevention & control
Science
Smooth muscle
Supplements
Vitamin D
Vitamin D - pharmacology
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Summary:Patients with pulmonary fibrosis often have low vitamin D levels, the effects of which are largely unknown. We here report that early vitamin D supplementation significantly reduced the severity of pulmonary fibrosis and inflammatory cell accumulationin in the bleomycin-induced pulmonary fibrosis mouse model on supplementary days 14, 21 and 28 ( P  
ISSN:2045-2322
2045-2322
DOI:10.1038/srep17638