Detection of occult paroxysmal atrial fibrilation by implantable long-term electrocardiographic monitoring in cryptogenic stroke and transient ischemic attack population: a study protocol for prospective matched cohort study

Cardio-embolic etiology is the most frequently predicted cause of cryptogenic stroke/TIA. Detection of occult paroxysmal atrial fibrillation is crucial for selection of appropriate medication. Enrolment of eligible cryptogenic stroke and TIA patients began in 2014 and will continue until 2018. The p...

Full description

Saved in:
Bibliographic Details
Published in:BMC cardiovascular disorders 2015-12, Vol.15 (1), p.160-160, Article 160
Main Authors: Petrovičová, Andrea, Kurča, Egon, Brozman, Miroslav, Hasilla, Jozef, Vahala, Pavel, Blaško, Peter, Andrášová, Andrea, Hatala, Robert, Urban, Luboš, Sivák, Štefan
Format: Article
Language:English
Subjects:
Atrial fibrillation
Atrial Fibrillation - diagnosis
Cerebral ischemia
Development and progression
Electrocardiogram
Electrocardiography
Electrocardiography, Ambulatory - methods
Gene mutations
Genetic aspects
Homeobox Protein PITX2
Homeodomain Proteins - genetics
Humans
Implants, Artificial
Ischemic Attack, Transient - complications
Ischemic Attack, Transient - genetics
Matched-Pair Analysis
Mutation
Patient compliance
Prospective Studies
Prosthesis
Stroke (Disease)
Stroke - complications
Stroke - genetics
Study Protocol
Transcription Factors - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cardio-embolic etiology is the most frequently predicted cause of cryptogenic stroke/TIA. Detection of occult paroxysmal atrial fibrillation is crucial for selection of appropriate medication. Enrolment of eligible cryptogenic stroke and TIA patients began in 2014 and will continue until 2018. The patients undergo long-term (12 months) ECG monitoring (implantable loop recorder) and testing for PITX2 (chromosome 4q25) and ZFHX3 (chromosome 16q22) gene mutations. There will be an appropriate control group of age- and sex-matched healthy volunteers. To analyse the results descriptive statistics, statistical tests for group differences, and correlation analyses will be used. In our study we are focusing on a possible correlation between detection of atrial fibrillation by an implantable ECG recorder, and PITX2 and/or ZFHX3 gene mutations in cryptogenic stroke/TIA patients. A correlation could lead to implementation of this genomic approach to cryptogenic stroke/TIA diagnostics and management. The results will be published in 2018. ClinicalTrials.gov: NCT02216370 .
ISSN:1471-2261
1471-2261
DOI:10.1186/s12872-015-0160-8