Perinatal Oxidative Stress May Affect Fetal Ghrelin Levels in Humans

In vitro cell model studies have shown that oxidative stress may affect beta-cell function. It is unknown whether oxidative stress may affect metabolic health in human fetuses/newborns. In a singleton pregnancy cohort (n = 248), we studied maternal (24–28 weeks gestation) and cord plasma biomarkers...

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Published in:Scientific reports 2015-12, Vol.5 (1), p.17881-17881, Article 17881
Main Authors: Luo, Zhong-Cheng, Bilodeau, Jean-François, Monique Nuyt, Anne, Fraser, William D., Julien, Pierre, Audibert, Francois, Xiao, Lin, Garofalo, Carole, Levy, Emile
Format: Article
Language:English
Subjects:
692/308/1892
692/308/3187
82/16
82/51
82/58
Adiponectin
Adult
Beta cells
Biomarkers
F2-Isoprostanes - blood
F2-Isoprostanes - metabolism
Female
Fetal Blood - metabolism
Fetus - metabolism
Fetuses
Gestational Age
Ghrelin
Ghrelin - blood
Ghrelin - metabolism
Humanities and Social Sciences
Humans
Infant, Newborn
Insulin
Insulin-like growth factor I
Insulin-like growth factor II
Insulin-Secreting Cells
Isoprostanes
Leptin
Malondialdehyde
Malondialdehyde - blood
Malondialdehyde - metabolism
Metabolic disorders
Metabolic syndrome
Metabolism
multidisciplinary
Neonates
Oxidative Stress
Pregnancy
Science
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creator Luo, Zhong-Cheng
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Xiao, Lin
Garofalo, Carole
Levy, Emile
description In vitro cell model studies have shown that oxidative stress may affect beta-cell function. It is unknown whether oxidative stress may affect metabolic health in human fetuses/newborns. In a singleton pregnancy cohort (n = 248), we studied maternal (24–28 weeks gestation) and cord plasma biomarkers of oxidative stress [malondialdehyde (MDA), F2-isoprostanes] in relation to fetal metabolic health biomarkers including cord plasma glucose-to-insulin ratio (an indicator of insulin sensitivity), proinsulin-to-insulin ratio (an indicator of beta-cell function), insulin, IGF-I, IGF-II, leptin, adiponectin and ghrelin concentrations. Strong positive correlations were observed between maternal and cord plasma biomarkers of oxidative stress (r = 0.33 for MDA, r = 0.74 for total F2-isoprostanes, all p 
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It is unknown whether oxidative stress may affect metabolic health in human fetuses/newborns. In a singleton pregnancy cohort (n = 248), we studied maternal (24–28 weeks gestation) and cord plasma biomarkers of oxidative stress [malondialdehyde (MDA), F2-isoprostanes] in relation to fetal metabolic health biomarkers including cord plasma glucose-to-insulin ratio (an indicator of insulin sensitivity), proinsulin-to-insulin ratio (an indicator of beta-cell function), insulin, IGF-I, IGF-II, leptin, adiponectin and ghrelin concentrations. Strong positive correlations were observed between maternal and cord plasma biomarkers of oxidative stress (r = 0.33 for MDA, r = 0.74 for total F2-isoprostanes, all p &lt; 0.0001). Adjusting for gestational age at blood sampling, cord plasma ghrelin concentrations were consistently negatively correlated to oxidative stress biomarkers in maternal (r = −0.32, p &lt; 0.0001 for MDA; r = −0.31, p &lt; 0.0001 for F2-isoprostanes) or cord plasma (r = −0.13, p = 0.04 for MDA; r = −0.32, p &lt; 0.0001 for F2-isoprostanes). Other fetal metabolic health biomarkers were not correlated to oxidative stress. Adjusting for maternal and pregnancy characteristics, similar associations were observed. Our study provides the first preliminary evidence suggesting that oxidative stress may affect fetal ghrelin levels in humans. The implications in developmental “programming” the vulnerability to metabolic syndrome related disorders remain to be elucidated.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep17881</identifier><identifier>PMID: 26643495</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/1892 ; 692/308/3187 ; 82/16 ; 82/51 ; 82/58 ; Adiponectin ; Adult ; Beta cells ; Biomarkers ; F2-Isoprostanes - blood ; F2-Isoprostanes - metabolism ; Female ; Fetal Blood - metabolism ; Fetus - metabolism ; Fetuses ; Gestational Age ; Ghrelin ; Ghrelin - blood ; Ghrelin - metabolism ; Humanities and Social Sciences ; Humans ; Infant, Newborn ; Insulin ; Insulin-like growth factor I ; Insulin-like growth factor II ; Insulin-Secreting Cells ; Isoprostanes ; Leptin ; Malondialdehyde ; Malondialdehyde - blood ; Malondialdehyde - metabolism ; Metabolic disorders ; Metabolic syndrome ; Metabolism ; multidisciplinary ; Neonates ; Oxidative Stress ; Pregnancy ; Science</subject><ispartof>Scientific reports, 2015-12, Vol.5 (1), p.17881-17881, Article 17881</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Dec 2015</rights><rights>Copyright © 2015, Macmillan Publishers Limited 2015 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-f32b8d70621008ff0b321de722ba24f4ebcd0764735ffb7d0646b615c9dbafbf3</citedby><cites>FETCH-LOGICAL-c438t-f32b8d70621008ff0b321de722ba24f4ebcd0764735ffb7d0646b615c9dbafbf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1808194878/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1808194878?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26643495$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Zhong-Cheng</creatorcontrib><creatorcontrib>Bilodeau, Jean-François</creatorcontrib><creatorcontrib>Monique Nuyt, Anne</creatorcontrib><creatorcontrib>Fraser, William D.</creatorcontrib><creatorcontrib>Julien, Pierre</creatorcontrib><creatorcontrib>Audibert, Francois</creatorcontrib><creatorcontrib>Xiao, Lin</creatorcontrib><creatorcontrib>Garofalo, Carole</creatorcontrib><creatorcontrib>Levy, Emile</creatorcontrib><title>Perinatal Oxidative Stress May Affect Fetal Ghrelin Levels in Humans</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>In vitro cell model studies have shown that oxidative stress may affect beta-cell function. It is unknown whether oxidative stress may affect metabolic health in human fetuses/newborns. In a singleton pregnancy cohort (n = 248), we studied maternal (24–28 weeks gestation) and cord plasma biomarkers of oxidative stress [malondialdehyde (MDA), F2-isoprostanes] in relation to fetal metabolic health biomarkers including cord plasma glucose-to-insulin ratio (an indicator of insulin sensitivity), proinsulin-to-insulin ratio (an indicator of beta-cell function), insulin, IGF-I, IGF-II, leptin, adiponectin and ghrelin concentrations. Strong positive correlations were observed between maternal and cord plasma biomarkers of oxidative stress (r = 0.33 for MDA, r = 0.74 for total F2-isoprostanes, all p &lt; 0.0001). Adjusting for gestational age at blood sampling, cord plasma ghrelin concentrations were consistently negatively correlated to oxidative stress biomarkers in maternal (r = −0.32, p &lt; 0.0001 for MDA; r = −0.31, p &lt; 0.0001 for F2-isoprostanes) or cord plasma (r = −0.13, p = 0.04 for MDA; r = −0.32, p &lt; 0.0001 for F2-isoprostanes). Other fetal metabolic health biomarkers were not correlated to oxidative stress. Adjusting for maternal and pregnancy characteristics, similar associations were observed. Our study provides the first preliminary evidence suggesting that oxidative stress may affect fetal ghrelin levels in humans. 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Adjusting for gestational age at blood sampling, cord plasma ghrelin concentrations were consistently negatively correlated to oxidative stress biomarkers in maternal (r = −0.32, p &lt; 0.0001 for MDA; r = −0.31, p &lt; 0.0001 for F2-isoprostanes) or cord plasma (r = −0.13, p = 0.04 for MDA; r = −0.32, p &lt; 0.0001 for F2-isoprostanes). Other fetal metabolic health biomarkers were not correlated to oxidative stress. Adjusting for maternal and pregnancy characteristics, similar associations were observed. Our study provides the first preliminary evidence suggesting that oxidative stress may affect fetal ghrelin levels in humans. The implications in developmental “programming” the vulnerability to metabolic syndrome related disorders remain to be elucidated.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26643495</pmid><doi>10.1038/srep17881</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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subjects 692/308/1892
692/308/3187
82/16
82/51
82/58
Adiponectin
Adult
Beta cells
Biomarkers
F2-Isoprostanes - blood
F2-Isoprostanes - metabolism
Female
Fetal Blood - metabolism
Fetus - metabolism
Fetuses
Gestational Age
Ghrelin
Ghrelin - blood
Ghrelin - metabolism
Humanities and Social Sciences
Humans
Infant, Newborn
Insulin
Insulin-like growth factor I
Insulin-like growth factor II
Insulin-Secreting Cells
Isoprostanes
Leptin
Malondialdehyde
Malondialdehyde - blood
Malondialdehyde - metabolism
Metabolic disorders
Metabolic syndrome
Metabolism
multidisciplinary
Neonates
Oxidative Stress
Pregnancy
Science
title Perinatal Oxidative Stress May Affect Fetal Ghrelin Levels in Humans
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