Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus

Diabetes (DM) is prevalent in cirrhosis and may modulate the risk of hospitalization through gut dysbiosis. We aimed to define the role of gut microbiota on 90-day hospitalizations and of concomitant DM on microbiota. Cirrhotic outpatients with/without DM underwent stool and sigmoid mucosal microbia...

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Bibliographic Details
Published in:Scientific reports 2015-12, Vol.5 (1), p.18559-18559, Article 18559
Main Authors: Bajaj, Jasmohan S., Betrapally, Naga S., Hylemon, Phillip B., Thacker, Leroy R., Daita, Kalyani, Kang, Dae Joong, White, Melanie B., Unser, Ariel B., Fagan, Andrew, Gavis, Edith A., Sikaroodi, Masoumeh, Dalmet, Swati, Heuman, Douglas M., Gillevet, Patrick M.
Format: Article
Language:English
Subjects:
692/308/53/2422
692/4020/4021/1607/1604
Demography
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - microbiology
Feces - microbiology
Female
Gastrointestinal Microbiome
Hospitalization
Humanities and Social Sciences
Humans
Intestinal Mucosa - microbiology
Liver Cirrhosis - complications
Liver Cirrhosis - microbiology
Logistic Models
Male
Middle Aged
multidisciplinary
Principal Component Analysis
Science
Treatment Outcome
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Summary:Diabetes (DM) is prevalent in cirrhosis and may modulate the risk of hospitalization through gut dysbiosis. We aimed to define the role of gut microbiota on 90-day hospitalizations and of concomitant DM on microbiota. Cirrhotic outpatients with/without DM underwent stool and sigmoid mucosal microbial analysis and were followed for 90 days. Microbial composition was compared between those with/without DM and those who were hospitalized/not. Regression/ROC analyses for hospitalizations were performed using clinical and microbial features. 278 cirrhotics [39% hepatic encephalopathy (HE), 31%DM] underwent stool while 72 underwent mucosal analyses. Ultimately, 94 were hospitalized and they had higher MELD, proton pump inhibitor (PPI) use and HE without difference in DM. Stool/mucosal microbiota were significantly altered in those who were hospitalized (UNIFRAC p
ISSN:2045-2322
2045-2322
DOI:10.1038/srep18559