Adverse reactions following routine anticholinergic eye drops in a paediatric population: an observational cohort study

ObjectivesTo investigate the presence, nature and relationship to age, sex, ethnicity and body mass index (BMI) of adverse reactions following routine cycloplegic eye drops in children.DesignProspective observational cohort study.SettingOphthalmology outpatient clinic Dutch metropolitan hospital; Fe...

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Bibliographic Details
Published in:BMJ open 2015-01, Vol.5 (12), p.e008798
Main Authors: van Minderhout, Helena M, Joosse, Maurits V, Grootendorst, Diana C, Schalij-Delfos, Nicoline E
Format: Article
Language:English
Subjects:
Adolescent
Age
Bias
Body mass index
Child
Child, Preschool
Cross-Sectional Studies
Cyclopentolate - administration & dosage
Cyclopentolate - adverse effects
Drug dosages
Female
Hallucinations
Human subjects
Humans
Hyperactivity
Logistic Models
Male
Medical screening
Multivariate Analysis
Mydriatics - administration & dosage
Mydriatics - adverse effects
Ophthalmic Solutions - administration & dosage
Ophthalmic Solutions - adverse effects
Ophthalmology
Parents & parenting
Pediatrics
Population
Prospective Studies
Strabismus
Tropicamide - administration & dosage
Tropicamide - adverse effects
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Summary:ObjectivesTo investigate the presence, nature and relationship to age, sex, ethnicity and body mass index (BMI) of adverse reactions following routine cycloplegic eye drops in children.DesignProspective observational cohort study.SettingOphthalmology outpatient clinic Dutch metropolitan hospital; February, March and April 2009.ParticipantsChildren aged 3–14-year-old children receiving two drops of cyclopentolate 1% (C+C) or one drop of cyclopentolate 1% and one drop of tropicamide 1% (C+T). Patients were categorised by age (3–6, 7–10 and 11–14 years), sex, ethnicity and body mass index (BMI) (low, normal or high).Outcome measuresRate and nature of adverse reactions reported at 45 min following treatment. Crude and adjusted ORs for reporting an adverse reaction using stepwise regression analysis with BMI, age, ethnicity and sex.Results912 of 915 eligible patients participated (99.7%). Adverse reactions were reported for C+C in 10.3% and in C+T in 4.8% (42/408 and 24/504, p=0.002), respectively. Central effects were present in 95% in C+C and in 92% in C+T. Compared to C+T, an increased risk was present in C+C (crude OR 2.3 (1.4 to 3.9), p=0.002). Forward adjustment showed BMI to be an influencing factor in treatment (OR 3.1 (1.7 to 5.6), p
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2015-008798