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Disconnect between adipose tissue inflammation and cardiometabolic dysfunction in Ossabaw pigs
Objective The Ossabaw pig is emerging as an attractive model of human cardiometabolic disease because of its size and susceptibility to atherosclerosis, among other characteristics. The relationship between adipose tissue inflammation and metabolic dysfunction in this model was investigated here. Me...
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| Published in: | Obesity (Silver Spring, Md.) Md.), 2015-12, Vol.23 (12), p.2421-2429 |
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| Main Authors: | , , , , , , , , , , |
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| container_end_page | 2429 |
| container_issue | 12 |
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| container_title | Obesity (Silver Spring, Md.) |
| container_volume | 23 |
| creator | Vieira‐Potter, Victoria J. Lee, Sewon Bayless, David S. Scroggins, Rebecca J. Welly, Rebecca J. Fleming, Nicholas J. Smith, Thomas N. Meers, Grace M. Hill, Michael A. Rector, R. Scott Padilla, Jaume |
| description | Objective
The Ossabaw pig is emerging as an attractive model of human cardiometabolic disease because of its size and susceptibility to atherosclerosis, among other characteristics. The relationship between adipose tissue inflammation and metabolic dysfunction in this model was investigated here.
Methods
Young female Ossabaw pigs were fed a Western‐style high‐fat diet (HFD) (n = 4) or control low‐fat diet (LFD) (n = 4) for a period of 9 months and compared for cardiometabolic outcomes and adipose tissue inflammation.
Results
The HFD‐fed “OBESE” pigs were 2.5 times heavier (P |
| doi_str_mv | 10.1002/oby.21252 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4701582</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1754085238</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5132-6177242b3a44a41042fd1fe93b15d1dd4d6e3e8cf3f4cbdab0684563afa965363</originalsourceid><addsrcrecordid>eNp1kUuLFDEUhYMozkMX_gEpcOMseiY3r6raCDo-YaA3Crox5HEzZqhK2kqVTf974_TYqOAqgfPxcZJDyBOg50Apu8h2d86ASXaPHEPP6arl_ef7h3sHR-SklBtKhaISHpIjpiQTjMIx-fo6FpdTQjc3FuctYmqMj5tcsJljKQs2MYXBjKOZY65Z8o0zk495xNnYPETX-F0JS3K3eUzNuhRjzbbZxOvyiDwIZij4-O48JZ_evvl4-X51tX734fLl1cpJ4GyloG1rIcuNEEYAFSx4CNhzC9KD98Ir5Ni5wINw1htLVSek4iaYXkmu-Cl5sfduFjuid5jmyQx6M8XRTDudTdR_Jyl-09f5hxYtBdmxKnh-J5jy9wXLrMf6MTgMJmFeioZWCtpJxruKPvsHvcnLlOrzKqVE13HooVJne8pNuZQJw6EMUP1rNV1X07erVfbpn-0P5O-ZKnCxB7ZxwN3_TXr96ste-RNJ4qNJ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1764883191</pqid></control><display><type>article</type><title>Disconnect between adipose tissue inflammation and cardiometabolic dysfunction in Ossabaw pigs</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Vieira‐Potter, Victoria J. ; Lee, Sewon ; Bayless, David S. ; Scroggins, Rebecca J. ; Welly, Rebecca J. ; Fleming, Nicholas J. ; Smith, Thomas N. ; Meers, Grace M. ; Hill, Michael A. ; Rector, R. Scott ; Padilla, Jaume</creator><creatorcontrib>Vieira‐Potter, Victoria J. ; Lee, Sewon ; Bayless, David S. ; Scroggins, Rebecca J. ; Welly, Rebecca J. ; Fleming, Nicholas J. ; Smith, Thomas N. ; Meers, Grace M. ; Hill, Michael A. ; Rector, R. Scott ; Padilla, Jaume</creatorcontrib><description>Objective
The Ossabaw pig is emerging as an attractive model of human cardiometabolic disease because of its size and susceptibility to atherosclerosis, among other characteristics. The relationship between adipose tissue inflammation and metabolic dysfunction in this model was investigated here.
Methods
Young female Ossabaw pigs were fed a Western‐style high‐fat diet (HFD) (n = 4) or control low‐fat diet (LFD) (n = 4) for a period of 9 months and compared for cardiometabolic outcomes and adipose tissue inflammation.
Results
The HFD‐fed “OBESE” pigs were 2.5 times heavier (P < 0.001) than LFD‐fed “LEAN” pigs and developed severe obesity. HFD feeding caused pronounced dyslipidemia, hypertension, and insulin resistance (systemic and adipose), as well as induction of inflammatory genes, impairments in vasomotor reactivity to insulin, and atherosclerosis in the coronary arteries. Remarkably, visceral, subcutaneous, and perivascular adipose tissue inflammation (via FACS analysis and RT‐PCR) was not increased in OBESE pigs, nor were circulating inflammatory cytokines.
Conclusions
These findings reveal a disconnect between adipose tissue inflammation and cardiometabolic dysfunction induced by Western diet feeding in the Ossabaw pig model.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.21252</identifier><identifier>PMID: 26524201</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adipocytes ; Adipose Tissue - metabolism ; Animals ; Atherosclerosis ; Biomarkers - metabolism ; Blood pressure ; Body composition ; Body fat ; Cardiovascular disease ; Coronary Artery Disease - etiology ; Coronary vessels ; Diet ; Diet, Fat-Restricted ; Diet, High-Fat - adverse effects ; Disease Models, Animal ; Dyslipidemias - etiology ; Female ; Females ; Hogs ; Hypertension - etiology ; Inflammation ; Insulin - metabolism ; Insulin Resistance ; Metabolism ; Mortality ; Obesity ; Obesity - etiology ; Obesity - genetics ; Obesity - physiopathology ; Panniculitis - etiology ; Panniculitis - physiopathology ; Phenotype ; Random Allocation ; Rodents ; Studies ; Swine ; Tumor necrosis factor-TNF ; Weight control</subject><ispartof>Obesity (Silver Spring, Md.), 2015-12, Vol.23 (12), p.2421-2429</ispartof><rights>2015 The Obesity Society</rights><rights>2015 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Dec 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5132-6177242b3a44a41042fd1fe93b15d1dd4d6e3e8cf3f4cbdab0684563afa965363</citedby><cites>FETCH-LOGICAL-c5132-6177242b3a44a41042fd1fe93b15d1dd4d6e3e8cf3f4cbdab0684563afa965363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26524201$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vieira‐Potter, Victoria J.</creatorcontrib><creatorcontrib>Lee, Sewon</creatorcontrib><creatorcontrib>Bayless, David S.</creatorcontrib><creatorcontrib>Scroggins, Rebecca J.</creatorcontrib><creatorcontrib>Welly, Rebecca J.</creatorcontrib><creatorcontrib>Fleming, Nicholas J.</creatorcontrib><creatorcontrib>Smith, Thomas N.</creatorcontrib><creatorcontrib>Meers, Grace M.</creatorcontrib><creatorcontrib>Hill, Michael A.</creatorcontrib><creatorcontrib>Rector, R. Scott</creatorcontrib><creatorcontrib>Padilla, Jaume</creatorcontrib><title>Disconnect between adipose tissue inflammation and cardiometabolic dysfunction in Ossabaw pigs</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
The Ossabaw pig is emerging as an attractive model of human cardiometabolic disease because of its size and susceptibility to atherosclerosis, among other characteristics. The relationship between adipose tissue inflammation and metabolic dysfunction in this model was investigated here.
Methods
Young female Ossabaw pigs were fed a Western‐style high‐fat diet (HFD) (n = 4) or control low‐fat diet (LFD) (n = 4) for a period of 9 months and compared for cardiometabolic outcomes and adipose tissue inflammation.
Results
The HFD‐fed “OBESE” pigs were 2.5 times heavier (P < 0.001) than LFD‐fed “LEAN” pigs and developed severe obesity. HFD feeding caused pronounced dyslipidemia, hypertension, and insulin resistance (systemic and adipose), as well as induction of inflammatory genes, impairments in vasomotor reactivity to insulin, and atherosclerosis in the coronary arteries. Remarkably, visceral, subcutaneous, and perivascular adipose tissue inflammation (via FACS analysis and RT‐PCR) was not increased in OBESE pigs, nor were circulating inflammatory cytokines.
Conclusions
These findings reveal a disconnect between adipose tissue inflammation and cardiometabolic dysfunction induced by Western diet feeding in the Ossabaw pig model.</description><subject>Adipocytes</subject><subject>Adipose Tissue - metabolism</subject><subject>Animals</subject><subject>Atherosclerosis</subject><subject>Biomarkers - metabolism</subject><subject>Blood pressure</subject><subject>Body composition</subject><subject>Body fat</subject><subject>Cardiovascular disease</subject><subject>Coronary Artery Disease - etiology</subject><subject>Coronary vessels</subject><subject>Diet</subject><subject>Diet, Fat-Restricted</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Disease Models, Animal</subject><subject>Dyslipidemias - etiology</subject><subject>Female</subject><subject>Females</subject><subject>Hogs</subject><subject>Hypertension - etiology</subject><subject>Inflammation</subject><subject>Insulin - metabolism</subject><subject>Insulin Resistance</subject><subject>Metabolism</subject><subject>Mortality</subject><subject>Obesity</subject><subject>Obesity - etiology</subject><subject>Obesity - genetics</subject><subject>Obesity - physiopathology</subject><subject>Panniculitis - etiology</subject><subject>Panniculitis - physiopathology</subject><subject>Phenotype</subject><subject>Random Allocation</subject><subject>Rodents</subject><subject>Studies</subject><subject>Swine</subject><subject>Tumor necrosis factor-TNF</subject><subject>Weight control</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1kUuLFDEUhYMozkMX_gEpcOMseiY3r6raCDo-YaA3Crox5HEzZqhK2kqVTf974_TYqOAqgfPxcZJDyBOg50Apu8h2d86ASXaPHEPP6arl_ef7h3sHR-SklBtKhaISHpIjpiQTjMIx-fo6FpdTQjc3FuctYmqMj5tcsJljKQs2MYXBjKOZY65Z8o0zk495xNnYPETX-F0JS3K3eUzNuhRjzbbZxOvyiDwIZij4-O48JZ_evvl4-X51tX734fLl1cpJ4GyloG1rIcuNEEYAFSx4CNhzC9KD98Ir5Ni5wINw1htLVSek4iaYXkmu-Cl5sfduFjuid5jmyQx6M8XRTDudTdR_Jyl-09f5hxYtBdmxKnh-J5jy9wXLrMf6MTgMJmFeioZWCtpJxruKPvsHvcnLlOrzKqVE13HooVJne8pNuZQJw6EMUP1rNV1X07erVfbpn-0P5O-ZKnCxB7ZxwN3_TXr96ste-RNJ4qNJ</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Vieira‐Potter, Victoria J.</creator><creator>Lee, Sewon</creator><creator>Bayless, David S.</creator><creator>Scroggins, Rebecca J.</creator><creator>Welly, Rebecca J.</creator><creator>Fleming, Nicholas J.</creator><creator>Smith, Thomas N.</creator><creator>Meers, Grace M.</creator><creator>Hill, Michael A.</creator><creator>Rector, R. Scott</creator><creator>Padilla, Jaume</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201512</creationdate><title>Disconnect between adipose tissue inflammation and cardiometabolic dysfunction in Ossabaw pigs</title><author>Vieira‐Potter, Victoria J. ; Lee, Sewon ; Bayless, David S. ; Scroggins, Rebecca J. ; Welly, Rebecca J. ; Fleming, Nicholas J. ; Smith, Thomas N. ; Meers, Grace M. ; Hill, Michael A. ; Rector, R. Scott ; Padilla, Jaume</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5132-6177242b3a44a41042fd1fe93b15d1dd4d6e3e8cf3f4cbdab0684563afa965363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adipocytes</topic><topic>Adipose Tissue - metabolism</topic><topic>Animals</topic><topic>Atherosclerosis</topic><topic>Biomarkers - metabolism</topic><topic>Blood pressure</topic><topic>Body composition</topic><topic>Body fat</topic><topic>Cardiovascular disease</topic><topic>Coronary Artery Disease - etiology</topic><topic>Coronary vessels</topic><topic>Diet</topic><topic>Diet, Fat-Restricted</topic><topic>Diet, High-Fat - adverse effects</topic><topic>Disease Models, Animal</topic><topic>Dyslipidemias - etiology</topic><topic>Female</topic><topic>Females</topic><topic>Hogs</topic><topic>Hypertension - etiology</topic><topic>Inflammation</topic><topic>Insulin - metabolism</topic><topic>Insulin Resistance</topic><topic>Metabolism</topic><topic>Mortality</topic><topic>Obesity</topic><topic>Obesity - etiology</topic><topic>Obesity - genetics</topic><topic>Obesity - physiopathology</topic><topic>Panniculitis - etiology</topic><topic>Panniculitis - physiopathology</topic><topic>Phenotype</topic><topic>Random Allocation</topic><topic>Rodents</topic><topic>Studies</topic><topic>Swine</topic><topic>Tumor necrosis factor-TNF</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vieira‐Potter, Victoria J.</creatorcontrib><creatorcontrib>Lee, Sewon</creatorcontrib><creatorcontrib>Bayless, David S.</creatorcontrib><creatorcontrib>Scroggins, Rebecca J.</creatorcontrib><creatorcontrib>Welly, Rebecca J.</creatorcontrib><creatorcontrib>Fleming, Nicholas J.</creatorcontrib><creatorcontrib>Smith, Thomas N.</creatorcontrib><creatorcontrib>Meers, Grace M.</creatorcontrib><creatorcontrib>Hill, Michael A.</creatorcontrib><creatorcontrib>Rector, R. Scott</creatorcontrib><creatorcontrib>Padilla, Jaume</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vieira‐Potter, Victoria J.</au><au>Lee, Sewon</au><au>Bayless, David S.</au><au>Scroggins, Rebecca J.</au><au>Welly, Rebecca J.</au><au>Fleming, Nicholas J.</au><au>Smith, Thomas N.</au><au>Meers, Grace M.</au><au>Hill, Michael A.</au><au>Rector, R. Scott</au><au>Padilla, Jaume</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disconnect between adipose tissue inflammation and cardiometabolic dysfunction in Ossabaw pigs</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2015-12</date><risdate>2015</risdate><volume>23</volume><issue>12</issue><spage>2421</spage><epage>2429</epage><pages>2421-2429</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Objective
The Ossabaw pig is emerging as an attractive model of human cardiometabolic disease because of its size and susceptibility to atherosclerosis, among other characteristics. The relationship between adipose tissue inflammation and metabolic dysfunction in this model was investigated here.
Methods
Young female Ossabaw pigs were fed a Western‐style high‐fat diet (HFD) (n = 4) or control low‐fat diet (LFD) (n = 4) for a period of 9 months and compared for cardiometabolic outcomes and adipose tissue inflammation.
Results
The HFD‐fed “OBESE” pigs were 2.5 times heavier (P < 0.001) than LFD‐fed “LEAN” pigs and developed severe obesity. HFD feeding caused pronounced dyslipidemia, hypertension, and insulin resistance (systemic and adipose), as well as induction of inflammatory genes, impairments in vasomotor reactivity to insulin, and atherosclerosis in the coronary arteries. Remarkably, visceral, subcutaneous, and perivascular adipose tissue inflammation (via FACS analysis and RT‐PCR) was not increased in OBESE pigs, nor were circulating inflammatory cytokines.
Conclusions
These findings reveal a disconnect between adipose tissue inflammation and cardiometabolic dysfunction induced by Western diet feeding in the Ossabaw pig model.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26524201</pmid><doi>10.1002/oby.21252</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Obesity (Silver Spring, Md.), 2015-12, Vol.23 (12), p.2421-2429 |
| issn | 1930-7381 1930-739X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4701582 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adipocytes Adipose Tissue - metabolism Animals Atherosclerosis Biomarkers - metabolism Blood pressure Body composition Body fat Cardiovascular disease Coronary Artery Disease - etiology Coronary vessels Diet Diet, Fat-Restricted Diet, High-Fat - adverse effects Disease Models, Animal Dyslipidemias - etiology Female Females Hogs Hypertension - etiology Inflammation Insulin - metabolism Insulin Resistance Metabolism Mortality Obesity Obesity - etiology Obesity - genetics Obesity - physiopathology Panniculitis - etiology Panniculitis - physiopathology Phenotype Random Allocation Rodents Studies Swine Tumor necrosis factor-TNF Weight control |
| title | Disconnect between adipose tissue inflammation and cardiometabolic dysfunction in Ossabaw pigs |
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