Loading…
Cell mediated immune responses following revaccination with an influenza A/H5N1 vaccine
Highlights • CMI responses occurred following administration of an inactivated A/H5N1 vaccine. • High dose vaccine increased the magnitude of CMI response only in the unprimed subjects. • IFN-γ nSFC levels correlated with IFN-γ concentrations in PBMC supernatants.
Saved in:
| Published in: | Vaccine 2016-01, Vol.34 (4), p.547-554 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c583t-4f0eeae627ead3aab299dc4413afdfc0fb4e82d375a07bd083e872cc4ac20d7f3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c583t-4f0eeae627ead3aab299dc4413afdfc0fb4e82d375a07bd083e872cc4ac20d7f3 |
| container_end_page | 554 |
| container_issue | 4 |
| container_start_page | 547 |
| container_title | Vaccine |
| container_volume | 34 |
| creator | Mbawuike, Innocent N Atmar, Robert L Patel, Shital M Corry, David B Winokur, Patricia L Brady, Rebecca C Chen, Wilbur H Edwards, Kathryn M Creech, C. Buddy Walter, Emmanuel B Frey, Sharon E Belshe, Robert B Goll, Johannes B Hill, Heather Keitel, Wendy A |
| description | Highlights • CMI responses occurred following administration of an inactivated A/H5N1 vaccine. • High dose vaccine increased the magnitude of CMI response only in the unprimed subjects. • IFN-γ nSFC levels correlated with IFN-γ concentrations in PBMC supernatants. |
| doi_str_mv | 10.1016/j.vaccine.2015.11.055 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4713282</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0264410X15017053</els_id><sourcerecordid>1760858167</sourcerecordid><originalsourceid>FETCH-LOGICAL-c583t-4f0eeae627ead3aab299dc4413afdfc0fb4e82d375a07bd083e872cc4ac20d7f3</originalsourceid><addsrcrecordid>eNqNkk9v1DAQxSMEokvhI4AiceGS1GPHf3IpqlZAkSo4AIKb5XUmrZesvbWTrcqnx9EuBXqBkyX75zcz701RPAdSAwFxsq53xlrnsaYEeA1QE84fFAtQklWUg3pYLAgVTdUA-XZUPElpTQjhDNrHxREVgsu2lYvi6xKHodxg58yIXek2m8ljGTFtg0-Yyj4MQ7hx_jLf7Qua0QVf3rjxqjS-dL4fJvQ_THl2cs4_QHno6mnxqDdDwmeH87j48vbN5-V5dfHx3fvl2UVluWJj1fQE0aCgEk3HjFnRtu1s0wAzfddb0q8aVLRjkhsiVx1RDJWk1jbGUtLJnh0Xp3vd7bTKU1j0YzSD3ka3MfFWB-P03y_eXenLsNONBEYVzQKvDgIxXE-YRr1xyWZTjMcwJQ1SUCZ4K8X_oERxBUJm9OU9dB2m6LMTmeJSCEXEXJvvKRtDShH7u76B6DllvdYHP_WcsgbQOeX878WfQ9_9-hVrBl7vAczW7xxGnaxDb3PMEe2ou-D-WeL0noIdnHfWDN_xFtPvaXSimuhP86rNmwacgMxrxn4CDiXR0g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1757668062</pqid></control><display><type>article</type><title>Cell mediated immune responses following revaccination with an influenza A/H5N1 vaccine</title><source>Elsevier</source><creator>Mbawuike, Innocent N ; Atmar, Robert L ; Patel, Shital M ; Corry, David B ; Winokur, Patricia L ; Brady, Rebecca C ; Chen, Wilbur H ; Edwards, Kathryn M ; Creech, C. Buddy ; Walter, Emmanuel B ; Frey, Sharon E ; Belshe, Robert B ; Goll, Johannes B ; Hill, Heather ; Keitel, Wendy A</creator><creatorcontrib>Mbawuike, Innocent N ; Atmar, Robert L ; Patel, Shital M ; Corry, David B ; Winokur, Patricia L ; Brady, Rebecca C ; Chen, Wilbur H ; Edwards, Kathryn M ; Creech, C. Buddy ; Walter, Emmanuel B ; Frey, Sharon E ; Belshe, Robert B ; Goll, Johannes B ; Hill, Heather ; Keitel, Wendy A</creatorcontrib><description>Highlights • CMI responses occurred following administration of an inactivated A/H5N1 vaccine. • High dose vaccine increased the magnitude of CMI response only in the unprimed subjects. • IFN-γ nSFC levels correlated with IFN-γ concentrations in PBMC supernatants.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2015.11.055</identifier><identifier>PMID: 26657997</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adjuvant ; Adjuvants, Immunologic - administration & dosage ; Adult ; Advisors ; Age ; Age Factors ; Aged ; Allergy and Immunology ; Antigens ; Avian flu ; Cell mediated immune response ; Confidence intervals ; Cytokine ; Cytokines ; Cytokines - immunology ; Female ; Granzymes - immunology ; H5N1 ; Humans ; Illnesses ; Immunity, Cellular ; Immunization, Secondary ; Immunoglobulins ; Inactivated influenza vaccine ; Infections ; Influenza A Virus, H5N1 Subtype ; Influenza Vaccines - administration & dosage ; Influenza Vaccines - therapeutic use ; Influenza, Human - prevention & control ; Interferon-gamma - immunology ; Leukocytes, Mononuclear - immunology ; Male ; Middle Aged ; Studies ; Vaccines ; Vaccines, Inactivated - administration & dosage ; Vaccines, Inactivated - therapeutic use ; Young Adult</subject><ispartof>Vaccine, 2016-01, Vol.34 (4), p.547-554</ispartof><rights>Elsevier Ltd</rights><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Jan 20, 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c583t-4f0eeae627ead3aab299dc4413afdfc0fb4e82d375a07bd083e872cc4ac20d7f3</citedby><cites>FETCH-LOGICAL-c583t-4f0eeae627ead3aab299dc4413afdfc0fb4e82d375a07bd083e872cc4ac20d7f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26657997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mbawuike, Innocent N</creatorcontrib><creatorcontrib>Atmar, Robert L</creatorcontrib><creatorcontrib>Patel, Shital M</creatorcontrib><creatorcontrib>Corry, David B</creatorcontrib><creatorcontrib>Winokur, Patricia L</creatorcontrib><creatorcontrib>Brady, Rebecca C</creatorcontrib><creatorcontrib>Chen, Wilbur H</creatorcontrib><creatorcontrib>Edwards, Kathryn M</creatorcontrib><creatorcontrib>Creech, C. Buddy</creatorcontrib><creatorcontrib>Walter, Emmanuel B</creatorcontrib><creatorcontrib>Frey, Sharon E</creatorcontrib><creatorcontrib>Belshe, Robert B</creatorcontrib><creatorcontrib>Goll, Johannes B</creatorcontrib><creatorcontrib>Hill, Heather</creatorcontrib><creatorcontrib>Keitel, Wendy A</creatorcontrib><title>Cell mediated immune responses following revaccination with an influenza A/H5N1 vaccine</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Highlights • CMI responses occurred following administration of an inactivated A/H5N1 vaccine. • High dose vaccine increased the magnitude of CMI response only in the unprimed subjects. • IFN-γ nSFC levels correlated with IFN-γ concentrations in PBMC supernatants.</description><subject>Adjuvant</subject><subject>Adjuvants, Immunologic - administration & dosage</subject><subject>Adult</subject><subject>Advisors</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Allergy and Immunology</subject><subject>Antigens</subject><subject>Avian flu</subject><subject>Cell mediated immune response</subject><subject>Confidence intervals</subject><subject>Cytokine</subject><subject>Cytokines</subject><subject>Cytokines - immunology</subject><subject>Female</subject><subject>Granzymes - immunology</subject><subject>H5N1</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Immunity, Cellular</subject><subject>Immunization, Secondary</subject><subject>Immunoglobulins</subject><subject>Inactivated influenza vaccine</subject><subject>Infections</subject><subject>Influenza A Virus, H5N1 Subtype</subject><subject>Influenza Vaccines - administration & dosage</subject><subject>Influenza Vaccines - therapeutic use</subject><subject>Influenza, Human - prevention & control</subject><subject>Interferon-gamma - immunology</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Studies</subject><subject>Vaccines</subject><subject>Vaccines, Inactivated - administration & dosage</subject><subject>Vaccines, Inactivated - therapeutic use</subject><subject>Young Adult</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkk9v1DAQxSMEokvhI4AiceGS1GPHf3IpqlZAkSo4AIKb5XUmrZesvbWTrcqnx9EuBXqBkyX75zcz701RPAdSAwFxsq53xlrnsaYEeA1QE84fFAtQklWUg3pYLAgVTdUA-XZUPElpTQjhDNrHxREVgsu2lYvi6xKHodxg58yIXek2m8ljGTFtg0-Yyj4MQ7hx_jLf7Qua0QVf3rjxqjS-dL4fJvQ_THl2cs4_QHno6mnxqDdDwmeH87j48vbN5-V5dfHx3fvl2UVluWJj1fQE0aCgEk3HjFnRtu1s0wAzfddb0q8aVLRjkhsiVx1RDJWk1jbGUtLJnh0Xp3vd7bTKU1j0YzSD3ka3MfFWB-P03y_eXenLsNONBEYVzQKvDgIxXE-YRr1xyWZTjMcwJQ1SUCZ4K8X_oERxBUJm9OU9dB2m6LMTmeJSCEXEXJvvKRtDShH7u76B6DllvdYHP_WcsgbQOeX878WfQ9_9-hVrBl7vAczW7xxGnaxDb3PMEe2ou-D-WeL0noIdnHfWDN_xFtPvaXSimuhP86rNmwacgMxrxn4CDiXR0g</recordid><startdate>20160120</startdate><enddate>20160120</enddate><creator>Mbawuike, Innocent N</creator><creator>Atmar, Robert L</creator><creator>Patel, Shital M</creator><creator>Corry, David B</creator><creator>Winokur, Patricia L</creator><creator>Brady, Rebecca C</creator><creator>Chen, Wilbur H</creator><creator>Edwards, Kathryn M</creator><creator>Creech, C. Buddy</creator><creator>Walter, Emmanuel B</creator><creator>Frey, Sharon E</creator><creator>Belshe, Robert B</creator><creator>Goll, Johannes B</creator><creator>Hill, Heather</creator><creator>Keitel, Wendy A</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160120</creationdate><title>Cell mediated immune responses following revaccination with an influenza A/H5N1 vaccine</title><author>Mbawuike, Innocent N ; Atmar, Robert L ; Patel, Shital M ; Corry, David B ; Winokur, Patricia L ; Brady, Rebecca C ; Chen, Wilbur H ; Edwards, Kathryn M ; Creech, C. Buddy ; Walter, Emmanuel B ; Frey, Sharon E ; Belshe, Robert B ; Goll, Johannes B ; Hill, Heather ; Keitel, Wendy A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c583t-4f0eeae627ead3aab299dc4413afdfc0fb4e82d375a07bd083e872cc4ac20d7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adjuvant</topic><topic>Adjuvants, Immunologic - administration & dosage</topic><topic>Adult</topic><topic>Advisors</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Allergy and Immunology</topic><topic>Antigens</topic><topic>Avian flu</topic><topic>Cell mediated immune response</topic><topic>Confidence intervals</topic><topic>Cytokine</topic><topic>Cytokines</topic><topic>Cytokines - immunology</topic><topic>Female</topic><topic>Granzymes - immunology</topic><topic>H5N1</topic><topic>Humans</topic><topic>Illnesses</topic><topic>Immunity, Cellular</topic><topic>Immunization, Secondary</topic><topic>Immunoglobulins</topic><topic>Inactivated influenza vaccine</topic><topic>Infections</topic><topic>Influenza A Virus, H5N1 Subtype</topic><topic>Influenza Vaccines - administration & dosage</topic><topic>Influenza Vaccines - therapeutic use</topic><topic>Influenza, Human - prevention & control</topic><topic>Interferon-gamma - immunology</topic><topic>Leukocytes, Mononuclear - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Studies</topic><topic>Vaccines</topic><topic>Vaccines, Inactivated - administration & dosage</topic><topic>Vaccines, Inactivated - therapeutic use</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mbawuike, Innocent N</creatorcontrib><creatorcontrib>Atmar, Robert L</creatorcontrib><creatorcontrib>Patel, Shital M</creatorcontrib><creatorcontrib>Corry, David B</creatorcontrib><creatorcontrib>Winokur, Patricia L</creatorcontrib><creatorcontrib>Brady, Rebecca C</creatorcontrib><creatorcontrib>Chen, Wilbur H</creatorcontrib><creatorcontrib>Edwards, Kathryn M</creatorcontrib><creatorcontrib>Creech, C. Buddy</creatorcontrib><creatorcontrib>Walter, Emmanuel B</creatorcontrib><creatorcontrib>Frey, Sharon E</creatorcontrib><creatorcontrib>Belshe, Robert B</creatorcontrib><creatorcontrib>Goll, Johannes B</creatorcontrib><creatorcontrib>Hill, Heather</creatorcontrib><creatorcontrib>Keitel, Wendy A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library (ProQuest)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mbawuike, Innocent N</au><au>Atmar, Robert L</au><au>Patel, Shital M</au><au>Corry, David B</au><au>Winokur, Patricia L</au><au>Brady, Rebecca C</au><au>Chen, Wilbur H</au><au>Edwards, Kathryn M</au><au>Creech, C. Buddy</au><au>Walter, Emmanuel B</au><au>Frey, Sharon E</au><au>Belshe, Robert B</au><au>Goll, Johannes B</au><au>Hill, Heather</au><au>Keitel, Wendy A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell mediated immune responses following revaccination with an influenza A/H5N1 vaccine</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2016-01-20</date><risdate>2016</risdate><volume>34</volume><issue>4</issue><spage>547</spage><epage>554</epage><pages>547-554</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>Highlights • CMI responses occurred following administration of an inactivated A/H5N1 vaccine. • High dose vaccine increased the magnitude of CMI response only in the unprimed subjects. • IFN-γ nSFC levels correlated with IFN-γ concentrations in PBMC supernatants.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>26657997</pmid><doi>10.1016/j.vaccine.2015.11.055</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2016-01, Vol.34 (4), p.547-554 |
| issn | 0264-410X 1873-2518 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4713282 |
| source | Elsevier |
| subjects | Adjuvant Adjuvants, Immunologic - administration & dosage Adult Advisors Age Age Factors Aged Allergy and Immunology Antigens Avian flu Cell mediated immune response Confidence intervals Cytokine Cytokines Cytokines - immunology Female Granzymes - immunology H5N1 Humans Illnesses Immunity, Cellular Immunization, Secondary Immunoglobulins Inactivated influenza vaccine Infections Influenza A Virus, H5N1 Subtype Influenza Vaccines - administration & dosage Influenza Vaccines - therapeutic use Influenza, Human - prevention & control Interferon-gamma - immunology Leukocytes, Mononuclear - immunology Male Middle Aged Studies Vaccines Vaccines, Inactivated - administration & dosage Vaccines, Inactivated - therapeutic use Young Adult |
| title | Cell mediated immune responses following revaccination with an influenza A/H5N1 vaccine |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T22%3A16%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cell%20mediated%20immune%20responses%20following%20revaccination%20with%20an%20influenza%20A/H5N1%20vaccine&rft.jtitle=Vaccine&rft.au=Mbawuike,%20Innocent%20N&rft.date=2016-01-20&rft.volume=34&rft.issue=4&rft.spage=547&rft.epage=554&rft.pages=547-554&rft.issn=0264-410X&rft.eissn=1873-2518&rft_id=info:doi/10.1016/j.vaccine.2015.11.055&rft_dat=%3Cproquest_pubme%3E1760858167%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c583t-4f0eeae627ead3aab299dc4413afdfc0fb4e82d375a07bd083e872cc4ac20d7f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1757668062&rft_id=info:pmid/26657997&rfr_iscdi=true |