Nonenzymatic enantioselective synthesis of all-carbon quaternary centers through desymmetrization

[Display omitted] The asymmetric desymmetrization of meso or prochiral compounds containing an all-carbon quaternary center is an attractive alternative to classical synthetic approaches aimed at the asymmetric formation of a new C–C bond. This review focuses on nonenzymatic desymmetrizations that u...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 2015-11, Vol.56 (47), p.6523-6535
Main Author: Petersen, Kimberly S.
Format: Article
Language:English
Subjects:
All-carbon quaternary center
Asymmetric
Desymmetrization
Organocatalysis
Transition-metal catalysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] The asymmetric desymmetrization of meso or prochiral compounds containing an all-carbon quaternary center is an attractive alternative to classical synthetic approaches aimed at the asymmetric formation of a new C–C bond. This review focuses on nonenzymatic desymmetrizations that utilize transition metal catalysts or organocatalysts to distinguish between enantiotopic groups to generate enantioenriched compounds containing all-carbon quaternary stereocenters.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2015.09.134