Age-dependent inverse correlations in CSF and plasma amyloid-β(1–42) concentrations prior to amyloid plaque deposition in the brain of 3xTg-AD mice

• Published in: Scientific reports 2016-02, Vol.6 (1), p.20185-20185, Article 20185
• Main Authors: Cho, Soo Min, Lee, Sejin, Yang, Seung-Hoon, Kim, Hye Yun, Lee, Michael Jisoo, Kim, Hyunjin Vincent, Kim, Jiyoon, Baek, Seungyeop, Yun, Jin, Kim, Dohee, Kim, Yun Kyung, Cho, Yakdol, Woo, Jiwan, Kim, Tae Song, Kim, YoungSoo
• Format: Article
• Language: English
• Subjects: 631/378/1689/1283; 692/53/2421; 692/699/375/365/1283; 82; 82/51; Aging - blood; Aging - cerebrospinal fluid; Alzheimer Disease - blood; Alzheimer Disease - cerebrospinal fluid; Amyloid beta-Peptides - blood; Amyloid beta-Peptides - cerebrospinal fluid; Animals; Blood-Brain Barrier - metabolism; Brain - metabolism; Female; Humanities and Social Sciences; Humans; Immunohistochemistry; Mice, Transgenic; multidisciplinary; Peptide Fragments - blood; Peptide Fragments - cerebrospinal fluid; Phosphorylation; Plaque, Amyloid - blood; Plaque, Amyloid - cerebrospinal fluid; Protein Transport; Science
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/srep20185

Amyloid-β (Aβ) plays a critical role as a biomarker in Alzheimer’s disease (AD) diagnosis. In addition to its diagnostic potential in the brain, recent studies have suggested that changes of Aβ level in the plasma can possibly indicate AD onset. In this study, we found that plasma Aβ(1–42) concentration increases with age, while the concentration of Aβ(1–42) in the cerebrospinal fluid (CSF) decreases in APP swe , PS1 M146V and Tau P301L transgenic (3xTg-AD) mice, if measurements were made before formation of ThS-positive plaques in the brain. Our data suggests that there is an inverse correlations between the plasma and CSF Aβ(1–42) levels until plaques form in transgenic mice’s brains and that the plasma Aβ concentration possesses the diagnostic potential as a biomarker for diagnosis of early AD stages.