The spleen contributes to stroke induced neurodegeneration through interferon gamma signaling

Delayed neuronal death associated with stroke has been increasingly linked to the immune response to the injury. Splenectomy prior to middle cerebral artery occlusion (MCAO) is neuroprotective and significantly reduces neuroinflammation. The present study investigated whether splenic signaling occur...

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Bibliographic Details
Published in:Metabolic brain disease 2012-06, Vol.27 (2), p.131-141
Main Authors: Seifert, Hilary A., Leonardo, Christopher C., Hall, Aaron A., Rowe, Derrick D., Collier, Lisa A., Benkovic, Stanley A., Willing, Alison E., Pennypacker, Keith R.
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Brain
Brain Ischemia - pathology
Brain Ischemia - physiopathology
Cell Hypoxia
Cells, Cultured
Cerebral blood flow
Female
Fluoresceins
Fluorescent Dyes
gamma -Interferon
Immune response
Immunohistochemistry
Infarction, Middle Cerebral Artery - pathology
Inflammation
Injuries
Interferon-gamma - pharmacology
Interferon-gamma - physiology
Ischemia
Laser-Doppler Flowmetry
Ligation
Male
Metabolic Diseases
Metabolic disorders
Middle Cerebral Artery - physiology
Nerve Degeneration - physiopathology
Neurodegeneration
Neuroglia - metabolism
Neurology
Neurons - drug effects
Neurons - metabolism
Neuroprotection
Neurosciences
Oligodendroglia - metabolism
Oncology
Organic Chemicals
Original Paper
Pregnancy
Rats
Rats, Sprague-Dawley
Recombinant Proteins - pharmacology
Signal Transduction - physiology
Spleen
Spleen - metabolism
Spleen - physiopathology
Splenectomy
Stroke
Stroke - physiopathology
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Summary:Delayed neuronal death associated with stroke has been increasingly linked to the immune response to the injury. Splenectomy prior to middle cerebral artery occlusion (MCAO) is neuroprotective and significantly reduces neuroinflammation. The present study investigated whether splenic signaling occurs through interferon gamma (IFNγ). IFNγ was elevated early in spleens but later in the brains of rats following MCAO. Splenectomy decreased the amount of IFNγ in the infarct post-MCAO. Systemic administration of recombinant IFNγ abolished the protective effects of splenectomy with a concurrent increase in INFγ expression in the brain. These results suggest a role for spleen-derived IFNγ in stroke pathology.
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-012-9283-0