Research START: A Multimethod Study of Barriers and Accelerators of Recruiting Research Participants

Under‐recruitment into clinical trials is a common and costly problem that undermines medical research. To better understand barriers to recruitment into clinical trials in our region, we conducted a multimethod descriptive study. We initially surveyed investigators who had conducted or were current...

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Bibliographic Details
Published in:Clinical and translational science 2015-12, Vol.8 (6), p.647-654
Main Authors: Stein, Mark A., Shaffer, Michele, Echo‐Hawk, Abigail, Smith, Jody, Stapleton, Ann, Melvin, Ann
Format: Article
Language:English
Subjects:
Access to Information
Adult
Child
Clinical trials
Clinical Trials as Topic
Data Collection
Data Interpretation, Statistical
Drugs, Investigational
Electronic Health Records
Focus Groups
Humans
Original s
participant recruitment
Patient Selection
Pediatrics
Program Development
registries
regulatory science
Research Design
Translational Medical Research - methods
Translational Medical Research - organization & administration
Translational Medical Research - standards
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Summary:Under‐recruitment into clinical trials is a common and costly problem that undermines medical research. To better understand barriers to recruitment into clinical trials in our region, we conducted a multimethod descriptive study. We initially surveyed investigators who had conducted or were currently conducting studies that utilized an adult or pediatric clinical research center (n = 92). We then conducted focus groups and key informant interviews with investigators, coordinators, and other stakeholders in clinical and translational research (n = 32 individuals). Only 41% of respondents reported that they had or were successfully meeting recruitment goals and 24% of the closed studies actually met their targeted recruitment goals. Varied reasons were identified for poor recruitment but there was not a single investigator or study “phenotype” that predicted enrollment outcome. Investigators commonly recruited from their own practice or clinic, and 29% used a manual electronic medical record search. The majority of investigators would utilize a service that provides recruitment advice, including feasibility assessment and consultation, easier access to the electronic health record and assistance with institutional review board and other regulatory requirements. Our findings suggest potential benefits providing assistance across a range of services that can be individualized to the varied needs of clinical and translational investigators.
ISSN:1752-8054
1752-8062
DOI:10.1111/cts.12351