The New Era of Treatment for Obesity and Metabolic Disorders: Evidence and Expectations for Gut Microbiome Transplantation

Key Points: The microbiome has been implicated in the development of obesity. Conventional therapeutic methods have limited effectiveness for the treatment of obesity and prevention of related complications. Gut microbiome transplantation may represent an alternative and effective therapy for the tr...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2016-02, Vol.6, p.15-15
Main Authors: Jayasinghe, Thilini N, Chiavaroli, Valentina, Holland, David J, Cutfield, Wayne S, O'Sullivan, Justin M
Format: Article
Language:English
Subjects:
Fecal Microbiota Transplantation - methods
Gastrointestinal Microbiome - physiology
Gastrointestinal Tract - microbiology
Humans
Metabolic Diseases - therapy
Microbiology
Obesity - therapy
Probiotics - therapeutic use
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Summary:Key Points: The microbiome has been implicated in the development of obesity. Conventional therapeutic methods have limited effectiveness for the treatment of obesity and prevention of related complications. Gut microbiome transplantation may represent an alternative and effective therapy for the treatment of obesity. Obesity has reached epidemic proportions. Despite a better understanding of the underlying pathophysiology and growing treatment options, a significant proportion of obese patients do not respond to treatment. Recently, microbes residing in the human gastrointestinal tract have been found to act as an "endocrine" organ, whose composition and functionality may contribute to the development of obesity. Therefore, fecal/gut microbiome transplantation (GMT), which involves the transfer of feces from a healthy donor to a recipient, is increasingly drawing attention as a potential treatment for obesity. Currently the evidence for GMT effectiveness in the treatment of obesity is preliminary. Here, we summarize benefits, procedures, and issues associated with GMT, with a special focus on obesity.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2016.00015