Comparative speed of kill after treatment with Simparica™ (sarolaner) and Advantix®(imidacloprid + permethrin) against induced infestations of Dermacentor reticulatus on dogs

Ticks are common ectoparasites that infest dogs globally. Acaricides with rapid and sustained speed of kill are critical to control infestations and to reduce the risk of disease transmission. This study evaluated the speed of kill for 5 weeks after a single dose of orally administered Simparica™ (s...

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Bibliographic Details
Published in:Parasites & vectors 2016-02, Vol.9 (1), p.104-104, Article 104
Main Authors: Becskei, Csilla, Geurden, Thomas, Erasmus, Heidi, Cuppens, Otto, Mahabir, Sean P, Six, Robert H
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Dermacentor - drug effects
Dermacentor - physiology
Dog Diseases - drug therapy
Dog Diseases - parasitology
Dogs
Imidazoles - administration & dosage
Insecticides - administration & dosage
Neonicotinoids
Nitro Compounds - administration & dosage
Permethrin - administration & dosage
Placebos - administration & dosage
Random Allocation
Survival Analysis
Tick Infestations - drug therapy
Tick Infestations - parasitology
Tick Infestations - veterinary
Time Factors
Treatment Outcome
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Summary:Ticks are common ectoparasites that infest dogs globally. Acaricides with rapid and sustained speed of kill are critical to control infestations and to reduce the risk of disease transmission. This study evaluated the speed of kill for 5 weeks after a single dose of orally administered Simparica™ (sarolaner) against induced infestations with Dermacentor reticulatus on dogs, compared to Advantix® Spot-on solution for dogs (imidacloprid + permethrin). Twenty four dogs were randomly allocated to treatment with either a placebo tablet, a sarolaner tablet (at 2 to 4 mg/kg) or with Advantix® as per label instructions. Dogs were treated on Day 0 and tick counts were performed in situ at 8 and 12 hours and with removal of the ticks at 24 hours after treatment and subsequent re-infestations on Days 7, 14, 21, 28 and 35. Acaricidal efficacy was determined at each time point relative to live tick counts from the placebo-treated dogs. Based on arithmetic (geometric) mean tick counts, the efficacy of sarolaner was ≥75.6 % (89.6 %) within 8 hours of treatment and tick counts were significantly lower than placebo and imidacloprid + permethrin-treated dogs (P 
ISSN:1756-3305
1756-3305
DOI:10.1186/s13071-016-1377-9