Antiretroviral Drugs and Risk of Chronic Alanine Aminotransferase Elevation in Human Immunodeficiency Virus (HIV)-Monoinfected Persons: The Data Collection on Adverse Events of Anti-HIV Drugs Study

Background.  Although human immunodeficiency virus (HIV)-positive persons on antiretroviral therapy (ART) frequently have chronic liver enzyme elevation (cLEE), the underlying cause is often unclear. Methods.  Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study participants without chr...

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Published in:Open forum infectious diseases 2016-01, Vol.3 (1), p.ofw009-ofw009
Main Authors: Kovari, Helen, Sabin, Caroline A., Ledergerber, Bruno, Ryom, Lene, Reiss, Peter, Law, Matthew, Pradier, Christian, Dabis, Francois, d'Arminio Monforte, Antonella, Smith, Colette, de Wit, Stephane, Kirk, Ole, Lundgren, Jens D., Weber, Rainer
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Language:English
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Summary:Background.  Although human immunodeficiency virus (HIV)-positive persons on antiretroviral therapy (ART) frequently have chronic liver enzyme elevation (cLEE), the underlying cause is often unclear. Methods.  Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study participants without chronic viral hepatitis were observed to the earliest of cLEE (elevated aminotransferase ≥6 months), death, last follow-up, or January 2, 2014. Antiretroviral treatment exposure was categorized as follows: no exposure and ongoing short- and long-term exposure (
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofw009