CMV seropositivity and T‐cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ study

Summary Although chronic infection with cytomegalovirus (CMV) is known to drive T lymphocytes toward a senescent phenotype, it remains controversial whether and how CMV can cause coronary heart disease (CHD). To explore whether CMV seropositivity or T‐cell populations associated with immunosenescenc...

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Bibliographic Details
Published in:Aging cell 2016-04, Vol.15 (2), p.389-392
Main Authors: Spyridopoulos, Ioakim, Martin‐Ruiz, Carmen, Hilkens, Catharien, Yadegarfar, Mohammad E., Isaacs, John, Jagger, Carol, Kirkwood, Tom, Zglinicki, Thomas
Format: Article
Language:English
Subjects:
Age Factors
Aged, 80 and over
aging
Cardiovascular Diseases - blood
Cardiovascular Diseases - immunology
Cardiovascular Diseases - microbiology
Cardiovascular Diseases - mortality
CD4
CD8
Chronic Disease - mortality
Comparative analysis
Coronary heart disease
Cytomegalovirus
Cytomegalovirus infections
Cytomegalovirus Infections - blood
Cytomegalovirus Infections - immunology
Cytomegalovirus Infections - mortality
Cytomegalovirus Infections - pathology
Female
Humans
immunosenescence
Male
Memory (Computers)
Mortality
octogenarians
Patient outcomes
Prognosis
Short Take
survival
T cells
T lymphocytes
T-Lymphocytes - immunology
T-Lymphocytes - pathology
United Kingdom - epidemiology
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Summary:Summary Although chronic infection with cytomegalovirus (CMV) is known to drive T lymphocytes toward a senescent phenotype, it remains controversial whether and how CMV can cause coronary heart disease (CHD). To explore whether CMV seropositivity or T‐cell populations associated with immunosenescence were informative for adverse cardiovascular outcome in the very old, we prospectively analyzed peripheral blood samples from 751 octogenarians (38% males) from the Newcastle 85+ study for their power to predict survival during a 65‐month follow‐up (47.3% survival rate). CMV‐seropositive participants showed a higher prevalence of CHD (37.7% vs. 26.7%, P = 0.030) compared to CMV‐seronegative participants together with lower CD4/CD8 ratio (1.7 vs. 4.1, P 
ISSN:1474-9718
1474-9726
DOI:10.1111/acel.12430