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Sesame Lignans and Vitamin E Supplementation Improve Subjective Statuses and Anti-Oxidative Capacity in Healthy Humans With Feelings of Daily Fatigue
Sesamin has anti-oxidative functions in vivo. Fatigue is caused in part by oxidative stress. We evaluated whether sesame lignans (sesamin/episesamin=1/1, 10 mg) with vitamin E (55 mg of alpha-tocopherol) (SVE) could improve subjective statuses and anti-oxidative capacity in humans using questionnair...
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Published in: | Global journal of health science 2015-03, Vol.7 (6), p.1-10 |
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creator | Takemoto, Daisuke Yasutake, Yoko Tomimori, Namino Ono, Yoshiko Shibata, Hiroshi Hayashi, Junichi |
description | Sesamin has anti-oxidative functions in vivo. Fatigue is caused in part by oxidative stress. We evaluated whether sesame lignans (sesamin/episesamin=1/1, 10 mg) with vitamin E (55 mg of alpha-tocopherol) (SVE) could improve subjective statuses and anti-oxidative capacity in humans using questionnaires on fatigue, sleep and physical appearance, as well as low-density lipoprotein oxidation lag time. A placebo-controlled, double-blind, parallel-group study was conducted with subjects experiencing daily fatigue. After a run-in period, subjects were administered oral SVE or a placebo (P) for 8 weeks. A questionnaire regarding fatigue, sleep and physical appearance was conducted at 0, 4, and 8 weeks. Plasma low-density lipoprotein oxidation lag time was measured as an indicator of anti-oxidative capacity. The per-protocol analysis revealed significant improvements in fatigue status at 4 and 8 weeks compared to 0 weeks in both groups (p |
doi_str_mv | 10.5539/gjhs.v7n6p1 |
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Fatigue is caused in part by oxidative stress. We evaluated whether sesame lignans (sesamin/episesamin=1/1, 10 mg) with vitamin E (55 mg of alpha-tocopherol) (SVE) could improve subjective statuses and anti-oxidative capacity in humans using questionnaires on fatigue, sleep and physical appearance, as well as low-density lipoprotein oxidation lag time. A placebo-controlled, double-blind, parallel-group study was conducted with subjects experiencing daily fatigue. After a run-in period, subjects were administered oral SVE or a placebo (P) for 8 weeks. A questionnaire regarding fatigue, sleep and physical appearance was conducted at 0, 4, and 8 weeks. Plasma low-density lipoprotein oxidation lag time was measured as an indicator of anti-oxidative capacity. The per-protocol analysis revealed significant improvements in fatigue status at 4 and 8 weeks compared to 0 weeks in both groups (p<0.01), and sleep and physical appearance at 8 weeks compared to 0 weeks only in the SVE group (p<0.01). There were no significant differences observed between the groups. According to the 72-subject subgroup analysis (aged 40 and over), the sleep and physical appearance significantly improved compared to the P group (p<0.05), and fatigue status showed a tendency for improvement compared to the P group. Anti-oxidative capacity in the SVE group significantly increased compared to the P group (p<0.01). No adverse events relating to SVE supplementation were confirmed. These results suggest SVE supplementation could safely alleviate daily fatigue and oxidative stress.</description><identifier>ISSN: 1916-9736</identifier><identifier>EISSN: 1916-9744</identifier><identifier>DOI: 10.5539/gjhs.v7n6p1</identifier><identifier>PMID: 26153159</identifier><language>eng</language><publisher>Canada: Canadian Center of Science and Education</publisher><subject>Adult ; Antioxidants - therapeutic use ; Double-Blind Method ; Fatigue - drug therapy ; Female ; Humans ; Lignans - therapeutic use ; Male ; Oxidative Stress ; Sesamum ; Surveys and Questionnaires ; Treatment Outcome ; Vitamin E - therapeutic use</subject><ispartof>Global journal of health science, 2015-03, Vol.7 (6), p.1-10</ispartof><rights>Copyright: © Canadian Center of Science and Education 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c259t-2565e0b3e63abc077a40aa9caeee555f28a08d39a0248b892435b231df3c16223</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803842/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803842/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26153159$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takemoto, Daisuke</creatorcontrib><creatorcontrib>Yasutake, Yoko</creatorcontrib><creatorcontrib>Tomimori, Namino</creatorcontrib><creatorcontrib>Ono, Yoshiko</creatorcontrib><creatorcontrib>Shibata, Hiroshi</creatorcontrib><creatorcontrib>Hayashi, Junichi</creatorcontrib><title>Sesame Lignans and Vitamin E Supplementation Improve Subjective Statuses and Anti-Oxidative Capacity in Healthy Humans With Feelings of Daily Fatigue</title><title>Global journal of health science</title><addtitle>Glob J Health Sci</addtitle><description>Sesamin has anti-oxidative functions in vivo. Fatigue is caused in part by oxidative stress. We evaluated whether sesame lignans (sesamin/episesamin=1/1, 10 mg) with vitamin E (55 mg of alpha-tocopherol) (SVE) could improve subjective statuses and anti-oxidative capacity in humans using questionnaires on fatigue, sleep and physical appearance, as well as low-density lipoprotein oxidation lag time. A placebo-controlled, double-blind, parallel-group study was conducted with subjects experiencing daily fatigue. After a run-in period, subjects were administered oral SVE or a placebo (P) for 8 weeks. A questionnaire regarding fatigue, sleep and physical appearance was conducted at 0, 4, and 8 weeks. Plasma low-density lipoprotein oxidation lag time was measured as an indicator of anti-oxidative capacity. The per-protocol analysis revealed significant improvements in fatigue status at 4 and 8 weeks compared to 0 weeks in both groups (p<0.01), and sleep and physical appearance at 8 weeks compared to 0 weeks only in the SVE group (p<0.01). There were no significant differences observed between the groups. According to the 72-subject subgroup analysis (aged 40 and over), the sleep and physical appearance significantly improved compared to the P group (p<0.05), and fatigue status showed a tendency for improvement compared to the P group. Anti-oxidative capacity in the SVE group significantly increased compared to the P group (p<0.01). No adverse events relating to SVE supplementation were confirmed. These results suggest SVE supplementation could safely alleviate daily fatigue and oxidative stress.</description><subject>Adult</subject><subject>Antioxidants - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Fatigue - drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Lignans - therapeutic use</subject><subject>Male</subject><subject>Oxidative Stress</subject><subject>Sesamum</subject><subject>Surveys and Questionnaires</subject><subject>Treatment Outcome</subject><subject>Vitamin E - therapeutic use</subject><issn>1916-9736</issn><issn>1916-9744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNpVUU1v1DAQtRCIlsKJO_IRCaX4I3biC1K17bKVVuqhfBytSTLJepU4IXZW7A_h_5KwZQWnGc17896MHiFvObtWSpqPzX4Xrg-Z1wN_Ri654ToxWZo-P_dSX5BXIewZ01px9ZJcCM2V5Mpckl-PGKBDunWNBx8o-Ip-cxE65-kdfZyGocUOfYToek_vu2HsDzjPiz2W0S3tDE0BT5s3Prrk4aer4A-2ggFKF490FtsgtHF3pJupW3y-u7ija8TW-SbQvqa34NojXc-LzYSvyYsa2oBvnuoV-bq--7LaJNuHz_erm21SCmViIpRWyAqJWkJRsiyDlAGYEhBRKVWLHFheSQNMpHmRG5FKVQjJq1qWXAshr8ink-4wFR1W5fzoCK0dRtfBeLQ9OPs_4t3ONv3BpjmTeboIvH8SGPsfE4ZoOxdKbFvw2E_Bcm0Uz3Sq5Ez9cKKWYx_CiPXZhjO7BGmXIO0pyJn97t_Lzty_ycnfBt2eWQ</recordid><startdate>20150325</startdate><enddate>20150325</enddate><creator>Takemoto, Daisuke</creator><creator>Yasutake, Yoko</creator><creator>Tomimori, Namino</creator><creator>Ono, Yoshiko</creator><creator>Shibata, Hiroshi</creator><creator>Hayashi, Junichi</creator><general>Canadian Center of Science and Education</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150325</creationdate><title>Sesame Lignans and Vitamin E Supplementation Improve Subjective Statuses and Anti-Oxidative Capacity in Healthy Humans With Feelings of Daily Fatigue</title><author>Takemoto, Daisuke ; Yasutake, Yoko ; Tomimori, Namino ; Ono, Yoshiko ; Shibata, Hiroshi ; Hayashi, Junichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c259t-2565e0b3e63abc077a40aa9caeee555f28a08d39a0248b892435b231df3c16223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Antioxidants - therapeutic use</topic><topic>Double-Blind Method</topic><topic>Fatigue - drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Lignans - therapeutic use</topic><topic>Male</topic><topic>Oxidative Stress</topic><topic>Sesamum</topic><topic>Surveys and Questionnaires</topic><topic>Treatment Outcome</topic><topic>Vitamin E - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takemoto, Daisuke</creatorcontrib><creatorcontrib>Yasutake, Yoko</creatorcontrib><creatorcontrib>Tomimori, Namino</creatorcontrib><creatorcontrib>Ono, Yoshiko</creatorcontrib><creatorcontrib>Shibata, Hiroshi</creatorcontrib><creatorcontrib>Hayashi, Junichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Global journal of health science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takemoto, Daisuke</au><au>Yasutake, Yoko</au><au>Tomimori, Namino</au><au>Ono, Yoshiko</au><au>Shibata, Hiroshi</au><au>Hayashi, Junichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sesame Lignans and Vitamin E Supplementation Improve Subjective Statuses and Anti-Oxidative Capacity in Healthy Humans With Feelings of Daily Fatigue</atitle><jtitle>Global journal of health science</jtitle><addtitle>Glob J Health Sci</addtitle><date>2015-03-25</date><risdate>2015</risdate><volume>7</volume><issue>6</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>1916-9736</issn><eissn>1916-9744</eissn><abstract>Sesamin has anti-oxidative functions in vivo. Fatigue is caused in part by oxidative stress. We evaluated whether sesame lignans (sesamin/episesamin=1/1, 10 mg) with vitamin E (55 mg of alpha-tocopherol) (SVE) could improve subjective statuses and anti-oxidative capacity in humans using questionnaires on fatigue, sleep and physical appearance, as well as low-density lipoprotein oxidation lag time. A placebo-controlled, double-blind, parallel-group study was conducted with subjects experiencing daily fatigue. After a run-in period, subjects were administered oral SVE or a placebo (P) for 8 weeks. A questionnaire regarding fatigue, sleep and physical appearance was conducted at 0, 4, and 8 weeks. Plasma low-density lipoprotein oxidation lag time was measured as an indicator of anti-oxidative capacity. The per-protocol analysis revealed significant improvements in fatigue status at 4 and 8 weeks compared to 0 weeks in both groups (p<0.01), and sleep and physical appearance at 8 weeks compared to 0 weeks only in the SVE group (p<0.01). There were no significant differences observed between the groups. According to the 72-subject subgroup analysis (aged 40 and over), the sleep and physical appearance significantly improved compared to the P group (p<0.05), and fatigue status showed a tendency for improvement compared to the P group. Anti-oxidative capacity in the SVE group significantly increased compared to the P group (p<0.01). No adverse events relating to SVE supplementation were confirmed. These results suggest SVE supplementation could safely alleviate daily fatigue and oxidative stress.</abstract><cop>Canada</cop><pub>Canadian Center of Science and Education</pub><pmid>26153159</pmid><doi>10.5539/gjhs.v7n6p1</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Antioxidants - therapeutic use Double-Blind Method Fatigue - drug therapy Female Humans Lignans - therapeutic use Male Oxidative Stress Sesamum Surveys and Questionnaires Treatment Outcome Vitamin E - therapeutic use |
title | Sesame Lignans and Vitamin E Supplementation Improve Subjective Statuses and Anti-Oxidative Capacity in Healthy Humans With Feelings of Daily Fatigue |
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