The Barrier to Autointegration Factor: Interlocking Antiviral Defense with Genome Maintenance

Intrinsic defenses targeting foreign DNA are one facet of the cellular armament tasked with protecting host genomic integrity. The DNA binding protein BAF (barrier to autointegration factor) contributes to multiple aspects of genome maintenance and intercepts retrovirus, poxvirus, and herpesvirus ge...

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Bibliographic Details
Published in:Journal of virology 2016-04, Vol.90 (8), p.3806-3809
Main Authors: Wiebe, Matthew S, Jamin, Augusta
Format: Article
Language:English
Subjects:
DNA, Viral - metabolism
DNA-Binding Proteins - metabolism
Gems
Genome, Human
Humans
Nuclear Proteins - metabolism
Virus Integration
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Summary:Intrinsic defenses targeting foreign DNA are one facet of the cellular armament tasked with protecting host genomic integrity. The DNA binding protein BAF (barrier to autointegration factor) contributes to multiple aspects of genome maintenance and intercepts retrovirus, poxvirus, and herpesvirus genomes during infection. In this gem, we discuss the unique position BAF occupies at the virus-host interface and how both viral and cellular mechanisms may regulate its capacity to act as a pro- or antiviral effector targeting viral DNA.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.00178-16