Autophagy in dental tissues: a double-edged sword

Tooth development spans from the embryonic to the adolescent stage and can last for more than 10 years, which represents possibly the longest duration among all the human organs. The whole tooth development process ranges from the initial oral epithelium thickening to root formation and eruption. Ea...

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Bibliographic Details
Published in:Cell death & disease 2016-04, Vol.7 (4), p.e2192-e2192
Main Authors: Zhuang, H, Ali, K, Ardu, S, Tredwin, C, Hu, B
Format: Article
Language:English
Subjects:
13/1
631/80/82/39
692/699/3017
692/700/3032/3039
96/100
96/106
96/63
96/95
Aging
and
Anesthetics - pharmacology
Antibodies
Autophagy
Autophagy - drug effects
Bacterial Physiological Phenomena
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell Culture
Cell Differentiation - drug effects
Cell growth
Dentin
Developmental biology
Fluorides - pharmacology
Humans
Immunology
Life Sciences
news-and-commentary
Odontoblasts - cytology
Odontoblasts - metabolism
Periodontitis - etiology
Periodontitis - metabolism
Periodontitis - microbiology
Teeth
Tooth - cytology
Tooth - metabolism
Tooth - microbiology
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Summary:Tooth development spans from the embryonic to the adolescent stage and can last for more than 10 years, which represents possibly the longest duration among all the human organs. The whole tooth development process ranges from the initial oral epithelium thickening to root formation and eruption. Early tooth development results in rapid cell proliferation to provide sufficient cell number for populating the organ. The key events during later developments are involved in the differentiation of 'tooth-specific' cells such as ameloblasts, the epithelial origin cells that produce enamel, and odontoblasts, the mesenchymal origin cells that produce dentine.
ISSN:2041-4889
2041-4889
DOI:10.1038/cddis.2016.103