Skeletal muscle satellite cells are located at a closer proximity to capillaries in healthy young compared with older men

Background Skeletal muscle satellite cells (SC) are instrumental in maintenance of muscle fibres, the adaptive responses to exercise, and there is an age‐related decline in SC. A spatial relationship exists between SC and muscle fibre capillaries. In the present study, we aimed to investigate whethe...

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Published in:Journal of cachexia, sarcopenia and muscle sarcopenia and muscle, 2016-12, Vol.7 (5), p.547-554
Main Authors: Nederveen, Joshua P, Joanisse, Sophie, Snijders, Tim, Ivankovic, Victoria, Baker, Steven K., Phillips, Stuart M., Parise, Gianni
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aging
Biomarkers
Biopsy
Capillaries
Capillaries - metabolism
Cell Count
Cellular Microenvironment
Exercise
Fitness training programs
Fluorescent Antibody Technique
Growth factors
Healthy Volunteers
Humans
Immunoglobulins
Male
Middle Aged
Muscle Fibers, Skeletal - cytology
Muscle Fibers, Skeletal - metabolism
Muscle stem cells
Muscle, Skeletal - blood supply
Muscle, Skeletal - cytology
Muscle, Skeletal - metabolism
Musculoskeletal system
MyoD
Older people
Original
Pax7
Perfusion
Physical fitness
Satellite Cells, Skeletal Muscle - cytology
Satellite Cells, Skeletal Muscle - metabolism
Weightlifting
Young Adult
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cited_by cdi_FETCH-LOGICAL-c4765-ede9a4a8217fe8390a5753d57841ebac3dba021eb8c9270857fa34fd8f9f5ffa3
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container_issue 5
container_start_page 547
container_title Journal of cachexia, sarcopenia and muscle
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creator Nederveen, Joshua P
Joanisse, Sophie
Snijders, Tim
Ivankovic, Victoria
Baker, Steven K.
Phillips, Stuart M.
Parise, Gianni
description Background Skeletal muscle satellite cells (SC) are instrumental in maintenance of muscle fibres, the adaptive responses to exercise, and there is an age‐related decline in SC. A spatial relationship exists between SC and muscle fibre capillaries. In the present study, we aimed to investigate whether chronologic age has an impact on the spatial relationship between SC and muscle fibre capillaries. Secondly, we determined whether this spatial relationship changes in response to a single session of resistance exercise. Methods Muscle biopsies were obtained from the vastus lateralis of previously untrained young men (YM, 24 ± 3 years; n = 23) and older men (OM, 67 ± 4 years; n = 22) at rest. A subset of YM (n = 9) performed a single bout of resistance exercise, where additional muscle biopsies taken at 24 and 72 h post‐exercise recovery. Skeletal muscle fibre capillarization, SC content, and activation status were assessed using immunofluorescent microscopy of muscle cross sections. Results Type II muscle fibre SC and capillary content was significantly lower in the YM compared with OM (P 
doi_str_mv 10.1002/jcsm.12105
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A spatial relationship exists between SC and muscle fibre capillaries. In the present study, we aimed to investigate whether chronologic age has an impact on the spatial relationship between SC and muscle fibre capillaries. Secondly, we determined whether this spatial relationship changes in response to a single session of resistance exercise. Methods Muscle biopsies were obtained from the vastus lateralis of previously untrained young men (YM, 24 ± 3 years; n = 23) and older men (OM, 67 ± 4 years; n = 22) at rest. A subset of YM (n = 9) performed a single bout of resistance exercise, where additional muscle biopsies taken at 24 and 72 h post‐exercise recovery. Skeletal muscle fibre capillarization, SC content, and activation status were assessed using immunofluorescent microscopy of muscle cross sections. Results Type II muscle fibre SC and capillary content was significantly lower in the YM compared with OM (P &lt; 0.05). Furthermore, type II muscle fibre SC were located at a greater distance from the nearest capillary in OM compared with YM (21.6 ± 1.3 vs. 17.0 ± 0.8 µm, respectively; P &lt; 0.05). In response to a single bout of exercise, we observed a significant increase in SC number and activation status (P &lt; 0.05). In addition, activated vs. quiescent SC were situated closer (P &lt; 0.05) to capillaries. Conclusions We demonstrate that there is a greater distance between capillaries and type II fibre‐associated SC in OM as compared with YM. Furthermore, quiescent SC are located significantly further away from capillaries than active SC after single bout of exercise. Our data have implications for how muscle adapts to exercise and how aging may affect such adaptations.</description><identifier>ISSN: 2190-5991</identifier><identifier>EISSN: 2190-6009</identifier><identifier>DOI: 10.1002/jcsm.12105</identifier><identifier>PMID: 27239425</identifier><language>eng</language><publisher>Germany: John Wiley &amp; Sons, Inc</publisher><subject>Adult ; Age Factors ; Aged ; Aging ; Biomarkers ; Biopsy ; Capillaries ; Capillaries - metabolism ; Cell Count ; Cellular Microenvironment ; Exercise ; Fitness training programs ; Fluorescent Antibody Technique ; Growth factors ; Healthy Volunteers ; Humans ; Immunoglobulins ; Male ; Middle Aged ; Muscle Fibers, Skeletal - cytology ; Muscle Fibers, Skeletal - metabolism ; Muscle stem cells ; Muscle, Skeletal - blood supply ; Muscle, Skeletal - cytology ; Muscle, Skeletal - metabolism ; Musculoskeletal system ; MyoD ; Older people ; Original ; Pax7 ; Perfusion ; Physical fitness ; Satellite Cells, Skeletal Muscle - cytology ; Satellite Cells, Skeletal Muscle - metabolism ; Weightlifting ; Young Adult</subject><ispartof>Journal of cachexia, sarcopenia and muscle, 2016-12, Vol.7 (5), p.547-554</ispartof><rights>2016 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley &amp; Sons Ltd on behalf of the Society of Sarcopenia, Cachexia and Wasting Disorders</rights><rights>2016. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4765-ede9a4a8217fe8390a5753d57841ebac3dba021eb8c9270857fa34fd8f9f5ffa3</citedby><cites>FETCH-LOGICAL-c4765-ede9a4a8217fe8390a5753d57841ebac3dba021eb8c9270857fa34fd8f9f5ffa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2290128788/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2290128788?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,11562,25753,27924,27925,37012,44590,46052,46476,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27239425$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nederveen, Joshua P</creatorcontrib><creatorcontrib>Joanisse, Sophie</creatorcontrib><creatorcontrib>Snijders, Tim</creatorcontrib><creatorcontrib>Ivankovic, Victoria</creatorcontrib><creatorcontrib>Baker, Steven K.</creatorcontrib><creatorcontrib>Phillips, Stuart M.</creatorcontrib><creatorcontrib>Parise, Gianni</creatorcontrib><title>Skeletal muscle satellite cells are located at a closer proximity to capillaries in healthy young compared with older men</title><title>Journal of cachexia, sarcopenia and muscle</title><addtitle>J Cachexia Sarcopenia Muscle</addtitle><description>Background Skeletal muscle satellite cells (SC) are instrumental in maintenance of muscle fibres, the adaptive responses to exercise, and there is an age‐related decline in SC. A spatial relationship exists between SC and muscle fibre capillaries. In the present study, we aimed to investigate whether chronologic age has an impact on the spatial relationship between SC and muscle fibre capillaries. Secondly, we determined whether this spatial relationship changes in response to a single session of resistance exercise. Methods Muscle biopsies were obtained from the vastus lateralis of previously untrained young men (YM, 24 ± 3 years; n = 23) and older men (OM, 67 ± 4 years; n = 22) at rest. A subset of YM (n = 9) performed a single bout of resistance exercise, where additional muscle biopsies taken at 24 and 72 h post‐exercise recovery. Skeletal muscle fibre capillarization, SC content, and activation status were assessed using immunofluorescent microscopy of muscle cross sections. Results Type II muscle fibre SC and capillary content was significantly lower in the YM compared with OM (P &lt; 0.05). Furthermore, type II muscle fibre SC were located at a greater distance from the nearest capillary in OM compared with YM (21.6 ± 1.3 vs. 17.0 ± 0.8 µm, respectively; P &lt; 0.05). In response to a single bout of exercise, we observed a significant increase in SC number and activation status (P &lt; 0.05). In addition, activated vs. quiescent SC were situated closer (P &lt; 0.05) to capillaries. Conclusions We demonstrate that there is a greater distance between capillaries and type II fibre‐associated SC in OM as compared with YM. Furthermore, quiescent SC are located significantly further away from capillaries than active SC after single bout of exercise. 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Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>ProQuest - Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cachexia, sarcopenia and muscle</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nederveen, Joshua P</au><au>Joanisse, Sophie</au><au>Snijders, Tim</au><au>Ivankovic, Victoria</au><au>Baker, Steven K.</au><au>Phillips, Stuart M.</au><au>Parise, Gianni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skeletal muscle satellite cells are located at a closer proximity to capillaries in healthy young compared with older men</atitle><jtitle>Journal of cachexia, sarcopenia and muscle</jtitle><addtitle>J Cachexia Sarcopenia Muscle</addtitle><date>2016-12</date><risdate>2016</risdate><volume>7</volume><issue>5</issue><spage>547</spage><epage>554</epage><pages>547-554</pages><issn>2190-5991</issn><eissn>2190-6009</eissn><abstract>Background Skeletal muscle satellite cells (SC) are instrumental in maintenance of muscle fibres, the adaptive responses to exercise, and there is an age‐related decline in SC. A spatial relationship exists between SC and muscle fibre capillaries. In the present study, we aimed to investigate whether chronologic age has an impact on the spatial relationship between SC and muscle fibre capillaries. Secondly, we determined whether this spatial relationship changes in response to a single session of resistance exercise. Methods Muscle biopsies were obtained from the vastus lateralis of previously untrained young men (YM, 24 ± 3 years; n = 23) and older men (OM, 67 ± 4 years; n = 22) at rest. A subset of YM (n = 9) performed a single bout of resistance exercise, where additional muscle biopsies taken at 24 and 72 h post‐exercise recovery. Skeletal muscle fibre capillarization, SC content, and activation status were assessed using immunofluorescent microscopy of muscle cross sections. Results Type II muscle fibre SC and capillary content was significantly lower in the YM compared with OM (P &lt; 0.05). Furthermore, type II muscle fibre SC were located at a greater distance from the nearest capillary in OM compared with YM (21.6 ± 1.3 vs. 17.0 ± 0.8 µm, respectively; P &lt; 0.05). In response to a single bout of exercise, we observed a significant increase in SC number and activation status (P &lt; 0.05). In addition, activated vs. quiescent SC were situated closer (P &lt; 0.05) to capillaries. Conclusions We demonstrate that there is a greater distance between capillaries and type II fibre‐associated SC in OM as compared with YM. Furthermore, quiescent SC are located significantly further away from capillaries than active SC after single bout of exercise. Our data have implications for how muscle adapts to exercise and how aging may affect such adaptations.</abstract><cop>Germany</cop><pub>John Wiley &amp; Sons, Inc</pub><pmid>27239425</pmid><doi>10.1002/jcsm.12105</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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source Wiley Online Library Open Access; ProQuest - Publicly Available Content Database; PubMed Central
subjects Adult
Age Factors
Aged
Aging
Biomarkers
Biopsy
Capillaries
Capillaries - metabolism
Cell Count
Cellular Microenvironment
Exercise
Fitness training programs
Fluorescent Antibody Technique
Growth factors
Healthy Volunteers
Humans
Immunoglobulins
Male
Middle Aged
Muscle Fibers, Skeletal - cytology
Muscle Fibers, Skeletal - metabolism
Muscle stem cells
Muscle, Skeletal - blood supply
Muscle, Skeletal - cytology
Muscle, Skeletal - metabolism
Musculoskeletal system
MyoD
Older people
Original
Pax7
Perfusion
Physical fitness
Satellite Cells, Skeletal Muscle - cytology
Satellite Cells, Skeletal Muscle - metabolism
Weightlifting
Young Adult
title Skeletal muscle satellite cells are located at a closer proximity to capillaries in healthy young compared with older men
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