Acute oropharyngeal palsy is associated with antibodies to GQ1b and GT1a gangliosides

Three patients with acute oropharyngeal palsy had high titre anti-GQ1b and anti-GT1a IgG antibodies. No patients had ophthalmoplegia or ptosis. In all patients limb ataxia or areflexia were present without notable limb weakness. These patients describe an oropharyngeal variant of Guillain-Barré synd...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1996-12, Vol.61 (6), p.649-651
Main Authors: O'Leary, C P, Veitch, J, Durward, W F, Thomas, A M, Rees, J H, Willison, H J
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Female
Gangliosides - immunology
Humans
Male
Medical sciences
Middle Aged
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Oropharynx - immunology
Polyradiculoneuropathy - immunology
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Summary:Three patients with acute oropharyngeal palsy had high titre anti-GQ1b and anti-GT1a IgG antibodies. No patients had ophthalmoplegia or ptosis. In all patients limb ataxia or areflexia were present without notable limb weakness. These patients describe an oropharyngeal variant of Guillain-Barré syndrome in terms of anti-GQ1b antibody reactivity and show that high titre anti-GQ1b antibodies, serologically indistinguishable from those found in Miller Fisher syndrome, can occur in a clinical setting without ophthalmoplegia. The anti-GQ1b and anti-GT1a antibody assays may be helpful tests when considering the differential diagnosis of acute oropharyngeal palsy.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.61.6.649