Predicting macular hole closure with ocriplasmin based on spectral domain optical coherence tomography

Purpose To assess the preoperative features of patients with idiopathic macular hole (IMH) and vitreomacular adhesion (VMA) treated with ocriplasmin (OCP) that can predict successful closure. Method Data were prospectively collected on all patients with IMH treated with OCP in three British ophthalm...

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Bibliographic Details
Published in:Eye (London) 2016-05, Vol.30 (5), p.740-745
Main Authors: Steel, D H W, Parkes, C, Papastavrou, V T, Avery, P J, El-Ghrably, I A, Habib, M S, Sandinha, M T, Smith, J, Stannard, K P, Vaideanu-Collins, D, Hillier, R J
Format: Article
Language:English
Subjects:
59
631/378/2613/1786
692/1807/1482
692/698/1688/512/2613/1786
692/699/3161/3175
Aged
Aged, 80 and over
Clinical Study
Female
Fibrinolysin - therapeutic use
Fibrinolytic Agents - therapeutic use
Humans
Intravitreal Injections
Laboratory Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Ophthalmology
Peptide Fragments - therapeutic use
Pharmaceutical Sciences/Technology
Prospective Studies
Retina - drug effects
Retinal Perforations - diagnostic imaging
Retinal Perforations - drug therapy
Retinal Perforations - physiopathology
Surgery
Surgical Oncology
Tissue Adhesions - drug therapy
Tissue Adhesions - physiopathology
Tomography, Optical Coherence
Visual Acuity - physiology
Vitreous Body - drug effects
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Summary:Purpose To assess the preoperative features of patients with idiopathic macular hole (IMH) and vitreomacular adhesion (VMA) treated with ocriplasmin (OCP) that can predict successful closure. Method Data were prospectively collected on all patients with IMH treated with OCP in three British ophthalmic centres. Several preoperative variables were recorded including the IMH base diameter (BD), minimum linear diameter (MLD), and VMA width measured on spectral domain optical coherence tomography. Several other IMH indices were derived including a ‘width factor’, defined as the BD minus the MLD in μ m. The occurrence of VMA release and hole closure were used as the main outcome measures. Results Thirty-three patients in total with IMH were treated with OCP. Two patients developed rhegmatogenous retinal detachment and were excluded. The mean age of the remaining 31 patients was 71 years, and 71% were female. VMA release occurred in 19 of the 31 (61%) patients and macular hole closure in 11 (35%). Width factor was the most predictive feature for closure on multivariate analysis. The deviance R 2 was 67% ( P
ISSN:0950-222X
1476-5454
DOI:10.1038/eye.2016.42