In vivo assessment of human brain oscillations during application of transcranial electric currents

Brain oscillations reflect pattern formation of cell assemblies’ activity, which is often disturbed in neurological and psychiatric diseases like depression, schizophrenia and stroke. In the neurobiological analysis and treatment of these conditions, transcranial electric currents applied to the bra...

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Bibliographic Details
Published in:Nature communications 2013, Vol.4 (1), p.2032-2032, Article 2032
Main Authors: Soekadar, Surjo R., Witkowski, Matthias, Cossio, Eliana G., Birbaumer, Niels, Robinson, Stephen E., Cohen, Leonardo G.
Format: Article
Language:English
Subjects:
631/1647/1453
631/378
Adult
Brain
Brain - physiology
Brain Mapping
Electric currents
Electric Stimulation - methods
Electricity
Electrodes
Electroencephalography
Female
Humanities and Social Sciences
Humans
Image Processing, Computer-Assisted
Localization
Magnetoencephalography
Male
Motor Activity
multidisciplinary
Neurosciences
Phantoms, Imaging
Science
Science (multidisciplinary)
Sensors
Signal Processing, Computer-Assisted
Stroke
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Summary:Brain oscillations reflect pattern formation of cell assemblies’ activity, which is often disturbed in neurological and psychiatric diseases like depression, schizophrenia and stroke. In the neurobiological analysis and treatment of these conditions, transcranial electric currents applied to the brain proved beneficial. However, the direct effects of these currents on brain oscillations have remained an enigma because of the inability to record them simultaneously. Here we report a novel strategy that resolves this problem. We describe accurate reconstructed localization of dipolar sources and changes of brain oscillatory activity associated with motor actions in primary cortical brain regions undergoing transcranial electric stimulation. This new method allows for the first time direct measurement of the effects of non-invasive electrical brain stimulation on brain oscillatory activity and behavior. Transcranial brain stimulation is used to treat neurological and psychiatric disorders. Soekadar et al. describe a novel method that allows simultaneous measurements and transcranial brain stimulation of human oscillatory brain activity associated with motor actions in primary cortical brain regions.
ISSN:2041-1723
2041-1723
DOI:10.1038/ncomms3032