Novel application of chemical shift gradient echo in- and opposed-phase sequences in 3 T MRI for the detection of H-MRS visible lipids and grading of glioma

Objectives We evaluated the feasibility of using chemical shift gradient-echo (GE) in- and opposed-phase (IOP) imaging to grade glioma. Methods A phantom study was performed to investigate the correlation of 1 H MRS-visible lipids with the signal loss ratio (SLR) obtained using IOP imaging. A cross-...

Full description

Saved in:
Bibliographic Details
Published in:European radiology 2016-07, Vol.26 (7), p.2019-2029
Main Authors: Ramli, Norlisah, Khairy, Azua Mohd, Seow, Pohchoo, Tan, Li Kuo, Wong, Jeannie Hsiu Ding, Ganesan, Dharmendra, Rahmat, Kartini
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biopsy
Brain Neoplasms - classification
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - pathology
Child
Cross-Sectional Studies
Diagnostic Radiology
Feasibility Studies
Female
Glioma - classification
Glioma - diagnostic imaging
Glioma - pathology
Humans
Imaging
Internal Medicine
Interventional Radiology
Lipids
Lipids - administration & dosage
Magnetic Resonance
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy - methods
Male
Medicine
Medicine & Public Health
Metabolites
Middle Aged
Neuroradiology
Patients
Phantoms, Imaging
Radiology
Software
Spectrum analysis
Ultrasound
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives We evaluated the feasibility of using chemical shift gradient-echo (GE) in- and opposed-phase (IOP) imaging to grade glioma. Methods A phantom study was performed to investigate the correlation of 1 H MRS-visible lipids with the signal loss ratio (SLR) obtained using IOP imaging. A cross-sectional study approved by the institutional review board was carried out in 22 patients with different glioma grades. The patients underwent scanning using IOP imaging and single-voxel spectroscopy (SVS) using 3T MRI. The brain spectra acquisitions from solid and cystic components were obtained and correlated with the SLR for different grades. Results The phantom study showed a positive linear correlation between lipid quantification at 0.9 parts per million (ppm) and 1.3 ppm with SLR (r = 0.79–0.99, p 
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-015-4045-0