Cytokeratin and protein expression patterns in squamous cell carcinoma of the oral cavity provide evidence for two distinct pathogenetic pathways

Squamous cell carcinoma (SCC) of the oral cavity is a morphological heterogeneous disease. Various cytokeratin (CK) expression patterns with different prognostic values have been described, but little is known concerning the underlying biological cell mechanisms. Therefore, the present study investi...

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Bibliographic Details
Published in:Oncology letters 2016-07, Vol.12 (1), p.107-113
Main Authors: FROHWITTER, GESCHE, BUERGER, HORST, VAN DIEST, PAUL J, KORSCHING, EBERHARD, KLEINHEINZ, JOHANNES, FILLIES, THOMAS
Format: Article
Language:English
Subjects:
Alcohol
Antigens
Apoptosis
Care and treatment
Cell growth
cytokeratins
Cytoskeletal proteins
Development and progression
Epidermal growth factor
Gene expression
Genetic aspects
Glucose
Health aspects
Heat
Heat shock proteins
Hypoxia
Immunoglobulins
Lymphoma
Medical prognosis
Molecular weight
Mouth cancer
Oncology
oral cavity
Properties
Squamous cell carcinoma
Stem cells
Studies
Surgery
tumor biology
Tumors
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Summary:Squamous cell carcinoma (SCC) of the oral cavity is a morphological heterogeneous disease. Various cytokeratin (CK) expression patterns with different prognostic values have been described, but little is known concerning the underlying biological cell mechanisms. Therefore, the present study investigated 193 cases of oral SCCs using immunohistochemistry for α/β/γ-catenin, glucose transporter 1, caspase-3, X-linked inhibitor of apoptosis protein, hypoxia inducible factor-1α, carbonic anhydrase 9, heat shock protein (hsp) 70, mast/stem cell growth factor receptor, p21, p27, p16, p53, B-cell lymphoma 6, epidermal growth factor receptor, cyclin D1 and CK1, 5/6, 8/18, 10, 14 and 19. Expression patterns were analyzed with biomathematical permutation analysis. The present results revealed a significant association between the expression of low-molecular weight CK8/18 and 19 and a high-tumor grade, β and γ-catenin expression, deregulated cell cycle proteins and a predominant localization of the tumor on the floor of the mouth. By contrast, expression of high-molecular weight CK1, 5/6, 10 and 14 was significantly associated with the expression of p21 and hsp70. In conclusion, the current study presents evidence for the existence of two parallel pathogenetic pathways in oral SCCs, characterized by the expression of low- and high-molecular weight CKs. Additional studies are required to demonstrate the extent that these results may be used to improve therapeutic regimens.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2016.4588