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Attentional function and basal forebrain cholinergic neuron morphology during aging in the Ts65Dn mouse model of Down syndrome

Individuals with Down syndrome (DS) exhibit intellectual disability and develop Alzheimer’s disease-like neuropathology during the third decade of life. The Ts65Dn mouse model of DS exhibits key features of both disorders, including impairments in learning, attention and memory, as well as atrophy o...

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Published in:Brain Structure and Function 2016-12, Vol.221 (9), p.4337-4352
Main Authors: Powers, Brian E., Velazquez, Ramon, Kelley, Christy M., Ash, Jessica A., Strawderman, Myla S., Alldred, Melissa J., Ginsberg, Stephen D., Mufson, Elliott J., Strupp, Barbara J.
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container_issue 9
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container_title Brain Structure and Function
container_volume 221
creator Powers, Brian E.
Velazquez, Ramon
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Ash, Jessica A.
Strawderman, Myla S.
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Ginsberg, Stephen D.
Mufson, Elliott J.
Strupp, Barbara J.
description Individuals with Down syndrome (DS) exhibit intellectual disability and develop Alzheimer’s disease-like neuropathology during the third decade of life. The Ts65Dn mouse model of DS exhibits key features of both disorders, including impairments in learning, attention and memory, as well as atrophy of basal forebrain cholinergic neurons (BFCNs). The present study evaluated attentional function in relation to BFCN morphology in young (3 months) and middle-aged (12 months) Ts65Dn mice and disomic (2N) controls. Ts65Dn mice exhibited attentional dysfunction at both ages, with greater impairment in older trisomics. Density of BFCNs was significantly lower for Ts65Dn mice independent of age, which may contribute to attentional dysfunction since BFCN density was positively associated with performance on an attention task. BFCN volume decreased with age in 2N but not Ts65Dn mice. Paradoxically, BFCN volume was greater in older trisomic mice, suggestive of a compensatory response. In sum, attentional dysfunction occurred in both young and middle-aged Ts65Dn mice, which may in part reflect reduced density and/or phenotypic alterations in BFCNs.
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source Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List
subjects Aging
Animals
Attention - physiology
Basal Forebrain - metabolism
Basal Forebrain - pathology
Basal Forebrain - physiopathology
Biomedical and Life Sciences
Biomedicine
Cell Biology
Choline O-Acetyltransferase - metabolism
Cholinergic Neurons - metabolism
Cholinergic Neurons - pathology
Cholinergic Neurons - physiology
Disease Models, Animal
Down syndrome
Down Syndrome - pathology
Down Syndrome - physiopathology
Down Syndrome - psychology
Male
Mice
Mice, Transgenic
Neurology
Neurons
Neurosciences
Original Article
title Attentional function and basal forebrain cholinergic neuron morphology during aging in the Ts65Dn mouse model of Down syndrome
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