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Prognostic significance of annexin A2 and annexin A4 expression in patients with cervical cancer
The annexins (ANXs) have diverse roles in tumor development and progression, however, their clinical significance in cervical cancer has not been elucidated. The present study was to investigate the clinical significance of annexin A2 (ANXA2) and annexin A4 (ANXA4) expression in cervical cancer. ANX...
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| Published in: | BMC cancer 2016-07, Vol.16 (1), p.448-448, Article 448 |
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| creator | Choi, Chel Hun Chung, Joon-Yong Chung, Eun Joo Sears, John D Lee, Jeong-Won Bae, Duk-Soo Hewitt, Stephen M |
| description | The annexins (ANXs) have diverse roles in tumor development and progression, however, their clinical significance in cervical cancer has not been elucidated. The present study was to investigate the clinical significance of annexin A2 (ANXA2) and annexin A4 (ANXA4) expression in cervical cancer.
ANXA2 and ANXA4 immunohistochemical staining were performed on a cervical cancer tissue microarray consisting of 46 normal cervical epithelium samples and 336 cervical cancer cases and compared the data with clinicopathological variables, including the survival of cervical cancer patients.
ANXA2 expression was lower in cancer tissue (p = 0.002), whereas ANXA4 staining increased significantly in cancer tissues (p |
| doi_str_mv | 10.1186/s12885-016-2459-y |
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ANXA2 and ANXA4 immunohistochemical staining were performed on a cervical cancer tissue microarray consisting of 46 normal cervical epithelium samples and 336 cervical cancer cases and compared the data with clinicopathological variables, including the survival of cervical cancer patients.
ANXA2 expression was lower in cancer tissue (p = 0.002), whereas ANXA4 staining increased significantly in cancer tissues (p < 0.001). ANXA2 expression was more prominent in squamous cell carcinoma (p < 0.001), whereas ANXA4 was more highly expressed in adeno/adenosquamous carcinoma (p < 0.001). ANXA2 overexpression was positively correlated with advanced cancer phenotypes, whereas ANXA4 expression was associated with resistance to radiation with or without chemotherapy (p = 0.029). Notably, high ANXA2 and ANXA4 expression was significantly associated with shorter disease-free survival (p = 0.004 and p = 0.033, respectively). Multivariate analysis indicated that ANXA2+ (HR = 2.72, p = 0.003) and ANXA2+/ANXA4+ (HR = 2.69, p = 0.039) are independent prognostic factors of disease-free survival in cervical cancer. Furthermore, a random survival forest model using combined ANXA2, ANXA4, and clinical variables resulted in improved predictive power (mean C-index, 0.76) compared to that of clinical-variable-only models (mean C-index, 0.70) (p = 0.006).
These findings indicate that detecting ANXA2 and ANXA4 expression may aid the evaluation of cervical carcinoma prognosis.</description><identifier>ISSN: 1471-2407</identifier><identifier>EISSN: 1471-2407</identifier><identifier>DOI: 10.1186/s12885-016-2459-y</identifier><identifier>PMID: 27402115</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adult ; Analysis ; Annexin A2 - metabolism ; Annexin A4 - metabolism ; Biomarkers, Tumor - metabolism ; Carcinoma, Adenosquamous - mortality ; Carcinoma, Adenosquamous - pathology ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Care and treatment ; Cervical cancer ; Complications and side effects ; Disease-Free Survival ; Female ; Gene expression ; Humans ; Immunohistochemistry ; Metastasis ; Middle Aged ; Prognosis ; Risk factors ; Survival Analysis ; Tissue Array Analysis ; Uterine Cervical Neoplasms - mortality ; Uterine Cervical Neoplasms - pathology</subject><ispartof>BMC cancer, 2016-07, Vol.16 (1), p.448-448, Article 448</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>The Author(s). 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c559t-cbd2fd0a8a8730aa813868dcb6329c9390c10004d52b501381f5a23b9f44025d3</citedby><cites>FETCH-LOGICAL-c559t-cbd2fd0a8a8730aa813868dcb6329c9390c10004d52b501381f5a23b9f44025d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940752/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1807926049?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27402115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Chel Hun</creatorcontrib><creatorcontrib>Chung, Joon-Yong</creatorcontrib><creatorcontrib>Chung, Eun Joo</creatorcontrib><creatorcontrib>Sears, John D</creatorcontrib><creatorcontrib>Lee, Jeong-Won</creatorcontrib><creatorcontrib>Bae, Duk-Soo</creatorcontrib><creatorcontrib>Hewitt, Stephen M</creatorcontrib><title>Prognostic significance of annexin A2 and annexin A4 expression in patients with cervical cancer</title><title>BMC cancer</title><addtitle>BMC Cancer</addtitle><description>The annexins (ANXs) have diverse roles in tumor development and progression, however, their clinical significance in cervical cancer has not been elucidated. The present study was to investigate the clinical significance of annexin A2 (ANXA2) and annexin A4 (ANXA4) expression in cervical cancer.
ANXA2 and ANXA4 immunohistochemical staining were performed on a cervical cancer tissue microarray consisting of 46 normal cervical epithelium samples and 336 cervical cancer cases and compared the data with clinicopathological variables, including the survival of cervical cancer patients.
ANXA2 expression was lower in cancer tissue (p = 0.002), whereas ANXA4 staining increased significantly in cancer tissues (p < 0.001). ANXA2 expression was more prominent in squamous cell carcinoma (p < 0.001), whereas ANXA4 was more highly expressed in adeno/adenosquamous carcinoma (p < 0.001). ANXA2 overexpression was positively correlated with advanced cancer phenotypes, whereas ANXA4 expression was associated with resistance to radiation with or without chemotherapy (p = 0.029). Notably, high ANXA2 and ANXA4 expression was significantly associated with shorter disease-free survival (p = 0.004 and p = 0.033, respectively). Multivariate analysis indicated that ANXA2+ (HR = 2.72, p = 0.003) and ANXA2+/ANXA4+ (HR = 2.69, p = 0.039) are independent prognostic factors of disease-free survival in cervical cancer. Furthermore, a random survival forest model using combined ANXA2, ANXA4, and clinical variables resulted in improved predictive power (mean C-index, 0.76) compared to that of clinical-variable-only models (mean C-index, 0.70) (p = 0.006).
These findings indicate that detecting ANXA2 and ANXA4 expression may aid the evaluation of cervical carcinoma prognosis.</description><subject>Adult</subject><subject>Analysis</subject><subject>Annexin A2 - metabolism</subject><subject>Annexin A4 - metabolism</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Adenosquamous - mortality</subject><subject>Carcinoma, Adenosquamous - pathology</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Care and treatment</subject><subject>Cervical cancer</subject><subject>Complications and side effects</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Risk factors</subject><subject>Survival Analysis</subject><subject>Tissue Array Analysis</subject><subject>Uterine Cervical Neoplasms - mortality</subject><subject>Uterine Cervical Neoplasms - pathology</subject><issn>1471-2407</issn><issn>1471-2407</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNptkttu1DAQhiMEogd4AG5QJCRULlJ8TOwbpFXFoVIlEIdr4zhO1lXW3tpO2X17ZtnSbhDyhQ_zzW_P-C-KFxidYyzqtwkTIXiFcF0RxmW1fVQcY9Zg2KHm8cH6qDhJ6Roh3AgknhZHpGGIYMyPi59fYhh8SNmZMrnBu94Z7Y0tQ19q7-3G-XJBYNk9bFlpN-toU3LBl3Cw1tlZn1P5y-VlaWy8BY2x_KMTnxVPej0m-_xuPi1-fHj__eJTdfX54-XF4qoynMtcmbYjfYe00KKhSGuBqahFZ9qaEmkklchghBDrOGk5giDuuSa0lT2DUnhHT4t3e9311K5sZ-BBUY9qHd1Kx60K2ql5xLulGsKtYhIaxAkInN0JxHAz2ZTVyiVjx1F7G6aksEC0kYI2FNBX_6DXYYoeyttRjSQ1YvKBGvRolfN9gHvNTlQtGBeICM4EUOf_oWB0duVM8LZ3cD5LeDNLACbbTR70lJK6_PZ1zr4-YJdWj3mZwjhl-Lk0B_EeNDGkFG1_3ziM1M5rau81BV5TO6-pLeS8POz4fcZfc9HfSuTMkg</recordid><startdate>20160711</startdate><enddate>20160711</enddate><creator>Choi, Chel Hun</creator><creator>Chung, Joon-Yong</creator><creator>Chung, Eun Joo</creator><creator>Sears, John D</creator><creator>Lee, Jeong-Won</creator><creator>Bae, Duk-Soo</creator><creator>Hewitt, Stephen M</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160711</creationdate><title>Prognostic significance of annexin A2 and annexin A4 expression in patients with cervical cancer</title><author>Choi, Chel Hun ; Chung, Joon-Yong ; Chung, Eun Joo ; Sears, John D ; Lee, Jeong-Won ; Bae, Duk-Soo ; Hewitt, Stephen M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c559t-cbd2fd0a8a8730aa813868dcb6329c9390c10004d52b501381f5a23b9f44025d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>Annexin A2 - metabolism</topic><topic>Annexin A4 - metabolism</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma, Adenosquamous - mortality</topic><topic>Carcinoma, Adenosquamous - pathology</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Care and treatment</topic><topic>Cervical cancer</topic><topic>Complications and side effects</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Risk factors</topic><topic>Survival Analysis</topic><topic>Tissue Array Analysis</topic><topic>Uterine Cervical Neoplasms - mortality</topic><topic>Uterine Cervical Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Chel Hun</creatorcontrib><creatorcontrib>Chung, Joon-Yong</creatorcontrib><creatorcontrib>Chung, Eun Joo</creatorcontrib><creatorcontrib>Sears, John D</creatorcontrib><creatorcontrib>Lee, Jeong-Won</creatorcontrib><creatorcontrib>Bae, Duk-Soo</creatorcontrib><creatorcontrib>Hewitt, Stephen M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Proquest Health & Medical Complete</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Chel Hun</au><au>Chung, Joon-Yong</au><au>Chung, Eun Joo</au><au>Sears, John D</au><au>Lee, Jeong-Won</au><au>Bae, Duk-Soo</au><au>Hewitt, Stephen M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of annexin A2 and annexin A4 expression in patients with cervical cancer</atitle><jtitle>BMC cancer</jtitle><addtitle>BMC Cancer</addtitle><date>2016-07-11</date><risdate>2016</risdate><volume>16</volume><issue>1</issue><spage>448</spage><epage>448</epage><pages>448-448</pages><artnum>448</artnum><issn>1471-2407</issn><eissn>1471-2407</eissn><abstract>The annexins (ANXs) have diverse roles in tumor development and progression, however, their clinical significance in cervical cancer has not been elucidated. The present study was to investigate the clinical significance of annexin A2 (ANXA2) and annexin A4 (ANXA4) expression in cervical cancer.
ANXA2 and ANXA4 immunohistochemical staining were performed on a cervical cancer tissue microarray consisting of 46 normal cervical epithelium samples and 336 cervical cancer cases and compared the data with clinicopathological variables, including the survival of cervical cancer patients.
ANXA2 expression was lower in cancer tissue (p = 0.002), whereas ANXA4 staining increased significantly in cancer tissues (p < 0.001). ANXA2 expression was more prominent in squamous cell carcinoma (p < 0.001), whereas ANXA4 was more highly expressed in adeno/adenosquamous carcinoma (p < 0.001). ANXA2 overexpression was positively correlated with advanced cancer phenotypes, whereas ANXA4 expression was associated with resistance to radiation with or without chemotherapy (p = 0.029). Notably, high ANXA2 and ANXA4 expression was significantly associated with shorter disease-free survival (p = 0.004 and p = 0.033, respectively). Multivariate analysis indicated that ANXA2+ (HR = 2.72, p = 0.003) and ANXA2+/ANXA4+ (HR = 2.69, p = 0.039) are independent prognostic factors of disease-free survival in cervical cancer. Furthermore, a random survival forest model using combined ANXA2, ANXA4, and clinical variables resulted in improved predictive power (mean C-index, 0.76) compared to that of clinical-variable-only models (mean C-index, 0.70) (p = 0.006).
These findings indicate that detecting ANXA2 and ANXA4 expression may aid the evaluation of cervical carcinoma prognosis.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27402115</pmid><doi>10.1186/s12885-016-2459-y</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Analysis Annexin A2 - metabolism Annexin A4 - metabolism Biomarkers, Tumor - metabolism Carcinoma, Adenosquamous - mortality Carcinoma, Adenosquamous - pathology Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Care and treatment Cervical cancer Complications and side effects Disease-Free Survival Female Gene expression Humans Immunohistochemistry Metastasis Middle Aged Prognosis Risk factors Survival Analysis Tissue Array Analysis Uterine Cervical Neoplasms - mortality Uterine Cervical Neoplasms - pathology |
| title | Prognostic significance of annexin A2 and annexin A4 expression in patients with cervical cancer |
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