Monoubiquitination of Syntaxin 5 Regulates Golgi Membrane Dynamics during the Cell Cycle

The Golgi apparatus undergoes a ubiquitin-dependent disassembly and reassembly process during each cycle of cell division. Here we report the identification of the Golgi t-SNARE syntaxin 5 (Syn5) as the ubiquitinated substrate. Syn5 is monoubiquitinated by the ubiquitin ligase HACE1 in early mitosis...

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Bibliographic Details
Published in:Developmental cell 2016-07, Vol.38 (1), p.73-85
Main Authors: Huang, Shijiao, Tang, Danming, Wang, Yanzhuang
Format: Article
Language:English
Subjects:
Cell Cycle - physiology
Golgi Apparatus - physiology
HeLa Cells
Humans
Membrane Fusion - physiology
Mitosis - physiology
Protein Binding
Qa-SNARE Proteins - antagonists & inhibitors
Qa-SNARE Proteins - genetics
Qa-SNARE Proteins - metabolism
RNA, Small Interfering - genetics
Ubiquitin - metabolism
Ubiquitination
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