Oral fructose absorption in obese children with non-alcoholic fatty liver disease

• Published in: Pediatric obesity 2015-06, Vol.10 (3), p.188-195
• Main Authors: Sullivan, J. S., Le, M. T., Pan, Z., Rivard, C., Love-Osborne, K., Robbins, K., Johnson, R. J., Sokol, R. J., Sundaram, S. S.
• Format: Article
• Language: English
• Subjects: Acids; Adolescent; Biomarkers - metabolism; Blood Glucose - metabolism; Body Mass Index; Breath hydrogen; Breath Tests; Child; Childrens health; Eating; Female; Fructose - metabolism; Glucose; Hispanic people; Humans; Hydrogen - chemistry; Hydrogen - metabolism; hyperuricaemia; Insulin; Insulin - blood; Insulin Resistance; Liver diseases; malabsorption; Male; Non-alcoholic Fatty Liver Disease - metabolism; Obesity; Pediatrics; Predictive Value of Tests; Uric Acid - blood; Urine
• ISSN: 2047-6302; 2047-6310
• DOI: 10.1111/ijpo.238

Background Fructose intake is associated with non‐alcoholic fatty liver disease (NAFLD) development. Objective The objective of this study was to measure fructose absorption/metabolism in paediatric NAFLD compared with obese and lean controls. Methods Children with histologically proven NAFLD, and obese and lean controls received oral fructose (1 g kg−1 ideal body weight). Serum glucose, insulin, uric acid, and fructose, urine uric acid, urine fructose, and breath hydrogen levels were measured at baseline and multiple points until 360 min after fructose ingestion. Results Nine NAFLD (89% Hispanic, mean age 14.3 years, mean body mass index [BMI] 35.3 kg m−2), six obese controls (67% Hispanic, mean age 12.7 years, mean BMI 31.0 kg m−2) and nine lean controls (44% Hispanic, mean age 14.3 years, mean BMI 19.4 kg m−2) were enrolled. Following fructose ingestion, NAFLD vs. lean controls had elevated serum glucose, insulin and uric acid (P