Inhaled nitric oxide use in preterm infants in California neonatal intensive care units

Objective: To describe inhaled nitric oxide (iNO) exposure in preterm infants and variation in neonatal intensive care unit (NICU) use. Study Design: This was a retrospective cohort study of infants, 22 to 33+6/7 weeks of gestational age (GA), during 2005 to 2013. Analyses were stratified by GA and...

Full description

Saved in:
Bibliographic Details
Published in:Journal of perinatology 2016-08, Vol.36 (8), p.635-639
Main Authors: Handley, S C, Steinhorn, R H, Hopper, A O, Govindaswami, B, Bhatt, D R, Van Meurs, K P, Ariagno, R L, Gould, J B, Lee, H C
Format: Article
Language:English
Subjects:
692/308/409
692/700/1720
Administration, Inhalation
Analysis
Birth weight
Bronchodilator Agents - therapeutic use
California
Care and treatment
Collaboration
Exposure
FDA approval
Female
Gestational Age
Health aspects
Hospitals
Humans
Infant, Extremely Premature
Infant, Newborn
Infant, Premature, Diseases - drug therapy
Infant, Premature, Diseases - mortality
Infants
Infants (Premature)
Intensive care
Intensive care units
Intensive Care Units, Neonatal
Logistic Models
Male
Management
Medicine
Medicine & Public Health
Multivariate Analysis
Neonatal intensive care units
Neonates
Newborn babies
Nitric oxide
Nitric Oxide - therapeutic use
original-article
Pediatric Surgery
Pediatrics
Population characteristics
Premature babies
Retrospective Studies
Variation
Ventilators
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: To describe inhaled nitric oxide (iNO) exposure in preterm infants and variation in neonatal intensive care unit (NICU) use. Study Design: This was a retrospective cohort study of infants, 22 to 33+6/7 weeks of gestational age (GA), during 2005 to 2013. Analyses were stratified by GA and included population characteristics, iNO use over time and hospital variation. Results: Of the 65 824 infants, 1718 (2.61%) received iNO. Infants, 22 to 24+6/7 weeks of GA, had the highest incidence of iNO exposure (6.54%). Community NICUs ( n =77, median hospital use rate 0.7%) used less iNO than regional NICUs ( n =23, median hospital use rate 5.8%). In 22 to 24+6/7 weeks of GA infants, the median rate in regional centers was 10.6% (hospital interquartile range 3.8% to 22.6%). Conclusion: iNO exposure varied with GA and hospital level, with the most use in extremely premature infants and regional centers. Variation reflects a lack of consensus regarding the appropriate use of iNO for preterm infants.
ISSN:0743-8346
1476-5543
DOI:10.1038/jp.2016.49