Increased programmed death ligand-1 expression predicts poor prognosis in hepatocellular carcinoma patients

Accumulating studies have investigated the prognostic and clinical significance of programmed death ligand-1 (PD-L1) expression in patients with hepatocellular carcinoma (HCC); however, the results were conflicting and inconclusive. We conducted a meta-analysis to combine controversial data to preci...

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Bibliographic Details
Published in:OncoTargets and therapy 2016-01, Vol.9, p.4805-4813
Main Authors: Gu, Xiaobin, Gao, Xian-Shu, Xiong, Wei, Guo, Wei, Han, Linjun, Bai, Yun, Peng, Chuan, Cui, Ming, Xie, Mu
Format: Article
Language:English
Subjects:
Apoptosis
Brain cancer
Confidence intervals
Infections
Ligands
Liver cancer
Medical prognosis
Meta-analysis
Original Research
PD-L1 protein
Systematic review
Tumors
Viral infections
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Summary:Accumulating studies have investigated the prognostic and clinical significance of programmed death ligand-1 (PD-L1) expression in patients with hepatocellular carcinoma (HCC); however, the results were conflicting and inconclusive. We conducted a meta-analysis to combine controversial data to precisely evaluate this issue. Relevant studies were thoroughly searched on PubMed, Web of Science, and Embase until April 2016. Eligible studies were evaluated by selection criteria. Hazard ratio (HR) with 95% confidence interval (CI) was used to estimate the prognostic role of PD-L1 for overall survival (OS) and disease-free survival (DFS)/recurrence-free survival (RFS). Odds ratio (OR) with 95% CI were selected to assess the relationship between PD-L1 and clinicopathological features of HCC patients. Publication bias was tested using Begg's funnel plot. A total of seven studies published from 2009 to 2016 were included for meta-analysis. The data showed that high PD-L1 expression was correlated to shorter OS (HR =2.09, 95% CI: 1.66-2.64, P
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S110713