Assessment of anxiolytic effect of nerolidol in mice

Aim and Objectives: The present study was to assess the anxiolytic effect of nerolidol in mice. Materials and Methods: The anxiolytic activity was examined using the elevated plus maze (EPM) and open field test (OFT), and motor coordination by rotarod test. Thirty Swiss albino mice were divided into...

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Bibliographic Details
Published in:Indian journal of pharmacology 2016-07, Vol.48 (4), p.450-452
Main Authors: Goel, Rajesh, Kaur, Dilpreet, Pahwa, Priyanka
Format: Article
Language:English
Subjects:
Animal behavior
Animals
Anti-Anxiety Agents - pharmacology
Anxiety
Aromatherapy
Behavior, Animal - drug effects
Care and treatment
Dose-Response Relationship, Drug
Drug dosages
Experiments
Exploratory Behavior - drug effects
Health aspects
Male
Maze Learning - drug effects
Mental disorders
Mice, Inbred Strains
Motor ability
Oils & fats
Pharmaceuticals
Psychomotor Performance - drug effects
Psychotropic drugs
Rodents
Rotarod Performance Test
Sesquiterpenes
Sesquiterpenes - pharmacology
Short Communication
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Summary:Aim and Objectives: The present study was to assess the anxiolytic effect of nerolidol in mice. Materials and Methods: The anxiolytic activity was examined using the elevated plus maze (EPM) and open field test (OFT), and motor coordination by rotarod test. Thirty Swiss albino mice were divided into five groups of six mice each. Group 1 received vehicle control (normal saline); Group 2 received diazepam (1 mg/kg); Groups 3, 4, and 5 received nerolidol 12.5, 25, and 50 mg/kg, respectively. Results: Nerolidol (12.5, 25, and 50 mg/kg) significantly (P < 0.05) increased the time spent and a number of entries in open arm as compared to vehicle control in EPM test. In OFT, the nerolidol showed a significant (P < 0.05) increase in number of rearings and time spent in center and periphery, suggesting exploratory behavior of animals. Furthermore, nerolidol did not alter the fall down latency in rotarod test. Conclusion: Our findings indicated that nerolidol exerts an anxiolytic effect without altering the motor coordination.
ISSN:0253-7613
1998-3751
DOI:10.4103/0253-7613.186188