Urinary π-glutathione S-transferase Predicts Advanced Acute Kidney Injury Following Cardiovascular Surgery

Urinary biomarkers augment the diagnosis of acute kidney injury (AKI), with AKI after cardiovascular surgeries being a prototype of prognosis scenario. Glutathione S-transferases (GST) were evaluated as biomarkers of AKI. Urine samples were collected in 141 cardiovascular surgical patients and analy...

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Bibliographic Details
Published in:Scientific reports 2016-08, Vol.6 (1), p.26335-26335, Article 26335
Main Authors: Shu, Kai-Hsiang, Wang, Chih-Hsien, Wu, Che-Hsiung, Huang, Tao-Min, Wu, Pei-Chen, Lai, Chien-Heng, Tseng, Li-Jung, Tsai, Pi-Ru, Connolly, Rory, Wu, Vin-Cent
Format: Article
Language:English
Subjects:
692/4022/1585/4
692/53/2423
Acute Kidney Injury - diagnosis
Acute Kidney Injury - etiology
Acute Kidney Injury - mortality
Acute Kidney Injury - urine
Aged
Area Under Curve
Biomarkers - urine
Cardiovascular Diseases - mortality
Cardiovascular Diseases - surgery
Cardiovascular Surgical Procedures - adverse effects
Female
Glutathione S-Transferase pi - urine
Humanities and Social Sciences
Humans
Male
Middle Aged
multidisciplinary
Multivariate Analysis
Prognosis
Risk
ROC Curve
Science
Science (multidisciplinary)
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Summary:Urinary biomarkers augment the diagnosis of acute kidney injury (AKI), with AKI after cardiovascular surgeries being a prototype of prognosis scenario. Glutathione S-transferases (GST) were evaluated as biomarkers of AKI. Urine samples were collected in 141 cardiovascular surgical patients and analyzed for urinary alpha-(α-) and pi-(π-) GSTs. The outcomes of advanced AKI (KDIGO stage 2, 3) and all-cause in-patient mortality, as composite outcome, were recorded. Areas under the receiver operator characteristic (ROC) curves and multivariate generalized additive model (GAM) were applied to predict outcomes. Thirty-eight (26.9%) patients had AKI, while 12 (8.5%) were with advanced AKI. Urinary π-GST differentiated patients with/without advanced AKI or composite outcome after surgery (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep26335