Detection of Drug-Induced Acute Kidney Injury in Humans Using Urinary KIM-1, miR-21, -200c, and -423

Drug-induced acute kidney injury (AKI) is often encountered in hospitalized patients. Although serum creatinine (SCr) is still routinely used for assessing AKI, it is known to be insensitive and nonspecific. Therefore, our objective was to evaluate kidney injury molecule 1 (KIM-1) in conjunction wit...

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Bibliographic Details
Published in:Toxicological sciences 2016-07, Vol.152 (1), p.205-213
Main Authors: Pavkovic, Mira, Robinson-Cohen, Cassianne, Chua, Alicia S, Nicoara, Oana, Cárdenas-González, Mariana, Bijol, Vanesa, Ramachandran, Krithika, Hampson, Lucy, Pirmohamed, Munir, Antoine, Daniel J, Frendl, Gyorgy, Himmelfarb, Jonathan, Waikar, Sushrut S, Vaidya, Vishal S
Format: Article
Language:English
Subjects:
Acetaminophen - adverse effects
Acute Kidney Injury - chemically induced
Acute Kidney Injury - diagnosis
Acute Kidney Injury - genetics
Acute Kidney Injury - urine
Adult
Biomarkers - urine
Case-Control Studies
Cells, Cultured
Cisplatin - adverse effects
Cross-Sectional Studies
Dose-Response Relationship, Drug
Drug Overdose
Epithelial Cells - drug effects
Epithelial Cells - metabolism
Female
Hepatitis A Virus Cellular Receptor 1 - analysis
Humans
Kidney Tubules, Proximal - drug effects
Kidney Tubules, Proximal - metabolism
Longitudinal Studies
Male
MicroRNAs - genetics
MicroRNAs - urine
Middle Aged
Predictive Value of Tests
Time Factors
Urinalysis
Urinary microRNA Biomarkers of Acute Kidney Injury
Young Adult
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Summary:Drug-induced acute kidney injury (AKI) is often encountered in hospitalized patients. Although serum creatinine (SCr) is still routinely used for assessing AKI, it is known to be insensitive and nonspecific. Therefore, our objective was to evaluate kidney injury molecule 1 (KIM-1) in conjunction with microRNA (miR)-21, -200c, and -423 as urinary biomarkers for drug-induced AKI in humans. In a cross-sectional cohort of patients (n = 135) with acetaminophen (APAP) overdose, all 4 biomarkers were significantly (P 
ISSN:1096-6080
1096-0929
DOI:10.1093/toxsci/kfw077